CBD For Migraines: What Should You Expect?

Several days ago I was out to dinner for a buddy’s birthday and ended up getting into a pretty vile argument with a good friend about the “medical potential” of CBD. It was all pretty cliche; I went on and on and on about how manipulates receptors in our central nervous system, about how much safer it is than prescription meds, and on and on.

Turns out, there at the same table who ended up offering his two cents on the subject. While he said he does not specifically recommend CBD to his patients (more on that later), he did offer some fascinating insight from the medical/professional side of things. As a matter of fact, he had some specific things to say in particular about CBD oil for migraines. So for all of you migraine sufferers out there (and the National Institute of Health estimates there’s about 36 million of you), you might want to tune in to this one.

Conventional Migraine Treatments and Their Side Effects

Before we get into talking about CBD oil for migraines, let’s take a look at the most popular over the counter and prescription medication treatments, and their potential side effects.

The doctor I talked to said that generally, his first recommendation for migraine sufferers is that they try a simple over the counter combination analgesic like Excedrin. Which is basically a mixture of acetaminophen, aspirin, and caffeine. Though these are relatively safe if taken sporadically, they do pose significant risk of ulcers, kidney damage, and even stroke and heart attack for people who rely on them chronically.

In more severe or chronic cases of migraine, a class of drugs called triptans like Imitrex or Treximet is commonly prescribed. These drugs work by increasing serotonin levels and constricting blood vessels in the brain. And while they’re effective, they’re very prone to cause dizziness, nausea, extreme drowsiness, and/or tightness in the chest.

Another class of migraine medications called ergotamines and mild opioids like morphine and Oxycontin are also common prescriptions for acute migraine sufferers, though the side effects of these drugs are truly devastating. Opioid overdose deaths have quadrupled since 1999, and ergotamines like Migranal and Ergomar have been well-documented to promote heart attack, stroke, birth defects in pregnant women, and even toxicosis if taken along with antibiotics or antifungal medications.

Preventative (as opposed to acute onset) treatment options are also common, and these include drugs like verapamil (a calcium channel blocker), amitriptyline (an antidepressant), and anticonvulsants, which act by “calming” overactive nerves in the brain. While not as dangerous as ergotamines or opioids, preventative treatments can produce a sweeping array of side effects that range from nausea and low blood pressure, to weight gain and a decreased libido (low sex drive).

CBD for Migraines: What is CBD?

For the uninitiated, CBD (cannabidiol) is the non-psychoactive component of cannabis. This means that unlike THC, it doesn’t get you high. Rather, it works by interacting with an endogenous (naturally-occurring inside the body) network of cannabinoid receptors, specifically, G-protein coupled CB-1 and CB-2 receptors in the central nervous system. Under normal circumstances, these receptors interact with naturally-occurring endocannabinoids and influence such factors as – among other things – pain sensation, appetite, memory, and immune response.

If there is a deficiency or lack of naturally-occurring endocannabinoids in the body, the CB-1 and CB-2 receptors will have nothing to bind to, and therefore will not be able to carry out the chemical pathways required for healthy, normative functioning.

This is where CBD comes in. It acts as a supplement or “replacement” in the instance of an endocannabinoid deficiency. And the beauty of it is that, unlike THC, it can “do its job” and function perfectly well without having to entirely overwhelm the cannabinoid receptors (i.e., without having to get you stoned).

Think of it this way: you go to the doctor and discover that the chronic muscle cramping you’ve been suffering from is due to potassium deficiency. A simple enough fix, right? You eat some bananas and voila, the muscles can now function as they’re supposed to.

Same with CBD. Perhaps the migraines you’re suffering from are the result of an endocannabinoid deficiency in a particular area of the brain (migraines are thought to be related to endocannabinoid deficiencies), and they could be potentially remedied with a simple CBD regimen.

Current Research on CBD for Migraine Treatment

The major underlying problem with considering CBD as a viable treatment option for migraines is that there’s simply a lack of data and scientific research available to ‘quantify’ its effectiveness.

However, that’s not to say that there haven’t been any studies done on CBD oil for migraines. In fact, Forbes published an article on a recent study out of the European Academy of Neurology which showed the active compounds in CBD to be more effective at reducing acute migraine pain than prescription medications. And moreover, it also was shown to have fewer side effects than both amitriptyline and verapamil, which were the prescription meds in question.

And this only backs up a host of earlier publications that have showcased nearly identical results.

Some of the key numbers, in case you’re wondering?

Out of 121 adult participants, a daily dosage of CBD proved to decrease the number of overall migraines per month from 10.4 to 4.6.

The bottom line is, while there are a handful of publications out there that we can reference from, CBD is still a far cry away from receiving the kind of clinical attention that would be necessary for it to become a first-choice treatment option in a general medical setting. For the time being, we’ll have to continue relying on the minimal research that is out there, or better yet, continue relying on the millions of people who have already used it (and are still using it) to provide relief.

Best CBD Oil for Migraine?

Before you jump right into buying the very first oil you come across, bear in mind that some tinctures definitely have proven to be more effective at treating migraines than others. Here’s a quick look at some of the most well-known brands in terms of migraine treatment:

Brand Name
Our Score
  • Full-spectrum Hemp extract
  • No pesticides, solvents or chemical fertilizers
  • 3rd party laboratory tested
  • Price Range ($48.00 – $390.00)
20% Coupon Code: 20KANA
  • Full-Spectrum Extract (Made in USA)
  • 100% Natural and Organic
  • Contain no artificial flavors or preservatives
  • Prices range ($48-$125)
20% Coupon Code: 20JANE
  • High-grade CBD formula
  • All products are lab tested
  • Made from organically grown hemp
  • Price Range ($39-$139)
  • CBDPure uses a chemical-free CO2 extraction process
  • 3rd party laboratory tested
  • Certified hemp grown in Colorado
  • Price Range ($29.99 – $79.99)
  • Huge selection of CBD products
  • Implement natural hemp practices
  • Lab tested potency and purity
  • Price Range ($29 - $99)
  • Free shipping on orders over $99
  • Certificate of analysis for all products
  • Seed-to-sale hemp-based CBD products
  • Price Range ($19.99-$124.00)
  • All CBD products follow Good Manufacturing Protocols
  • Made from all-natural, non-GMO Colorado hemp
  • Community-minded brand
  • Local sourcing where possible
  • Price Range ($29.99-$199.99)
  • USDA certified organic
  • Broad-spectrum CBD formula (0.0% THC)
  • Family founded company
  • Made from USA-grown hemp
  • 3-day money back guarantee

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