The 10 Best CBD Oil Brands for Pain Relief [2022 Update]

It’s not easy living with pain. Whether you suffer from muscle spasms, chronic pain, arthritis, or general day-to-day soreness, finding a solution to help deal with your pain can make all the difference.

Over the last few years, CBD oil has become a popular method of managing pain. While CBD is not yet FDA-approved for pain relief, more doctors and scientific researchers are looking into its benefits.

The major advantage of CBD oil compared to traditional cannabis is that it doesn’t cause an intoxicating “high.” Due to the updated hemp legislature in the 2018 U.S. Farm Bill, CBD is widely available across the United States and dozens of countries worldwide.

However, with so many CBD companies to choose from, how do you find the best CBD oil for pain?

In this article, we highlight the realistic medical potential of CBD oil in terms of improving pain symptoms. We also highlight what we believe are the top 10 CBD brands that made our list based on CBD oil quality, effectiveness, customer service, and price. Finally, we outline what you need to consider when choosing a CBD brand. Let’s begin!

(This article is updated constantly, so check back from time to time to view the most updated information).

WayofLeaf works hard to earn your trust and provide well-researched and accurate information. Here you can read about How we select our products.

CBD Quick Snapshot

Editor’s choice
  • Hemp grown in Kentucky
  • No pesticides, solvents, or chemical fertilizers
  • 3rd party laboratory tested
  • Available worldwide
20% Coupon Code: 20KANA
  • Offers full-spectrum extract (made in USA)
  • Extracted with CO2
  • Uses no artificial flavors or preservatives
  • 30-day return policy
20% Coupon Code: 20JANE
  • High-grade CBD formula
  • All products are lab tested
  • Made from organically grown hemp
  • Uses a solvent-free extraction
20% Coupon Code: 20CBDOFF
  • Uses a chemical-free CO2 extraction process
  • 3rd party laboratory tested
  • Certified hemp grown in Colorado
  • Offers a full-spectrum formula
15% Coupon Code: CBDPure15
  • Full-spectrum extract
  • Derived from non-GMO hemp
  • Lab-tested by 3rd parties
  • Offers high strength of 5000mg
20% Coupon Code: 20OFFCBD1
  • Popular, top-selling USA brand
  • Developed by the world-famous Stanley Brothers
  • 15% off for military veterans
  • Featured on CNN and The New York Times
15% Coupon Code: 15OFFCW
  • Wide selection of CBD dabs, isolates, & concentrates
  • Crafted with non-GMO hemp
  • Low price options for first time CBD users
  • 99% pure CBD isolate
15% Coupon Code: 15OFFCBD
  • Premium broad-spectrum (0% THC) products
  • Refined extraction process for purity & consistency
  • Extensively lab-tested
  • 30-day money-back guarantee
20% Coupon Code: 20CBDOFF
  • Medicinal grade hemp extract
  • Fantastic range of CBD oils, edibles, vapes & more
  • Fast shipping, industry-leading customer service
  • Produced in small batches for consistency
10% Coupon Code: TOPQUALITY10
  • Sustainable seed-to-shelf operation
  • Sourced from 100% certified organic hemp
  • Featured in Us Weekly and Men’s Health
  • Specific products for sleep and stress
10% Coupon Code: SAVE10

CBD Oil for Pain Relief

We know through numerous studies that cannabis (i.e., medical marijuana) is sometimes used as a substitute for prescription painkillers. Yet, the intoxicating effects associated with marijuana make it unappealing for many users.

Cannabidiol (CBD), a non-intoxicating cannabis extract, is also used for various medical conditions – including pain relief. We see that some of the best CBD oils may have a positive impact in terms of pain management.

However, it’s important to remind readers that CBD oil isn’t approved by the U.S. Food and Drug Administration (FDA) for pain management. This means that the products and statements made in this article are also not evaluated by the FDA. As a result, we must point out that CBD is not intended to diagnose, treat, cure, or prevent any disease or medical condition.

However, CBD has received significant attention even without the FDA’s approval. You’ve likely seen featured stories on top news networks or have seen/read about CBD being recommended by high-profile social figures for various forms of pain relief.

For instance, Charlotte’s Web, a company once branded by Yahoo Finance as “the world’s leading CBD brand by market share,” has been featured numerous times on sites such as CNN and The Wall Street Journal and in popular fitness magazines like Men’s Health.

So, is there any evidence that CBD oil can help pain, or is it all hype with little substance or proof?

How Effective Is CBD Oil for Pain?

A growing number of people use CBD to help manage pain. Some users claim that the cannabinoid provides them with excellent pain relief and say it helps reduce their reliance on painkillers.

We have an endocannabinoid system (ECS), a cell-signaling system in the body. Researchers have found that CBD impacts ECS receptors in the immune system in particular. These receptors work when they receive chemical signals and ensure our cells respond to the stimuli. The result is an anti-inflammatory effect that helps reduce pain and associated swelling.

What Do the Studies Say?

The number of studies into CBD’s effect on pain is increasing rapidly. A study published in the European Journal of Pain looked at the impact of transdermal CBD on rats with induced arthritis. The researchers applied CBD gels to the rats’ pain sites in four different concentrations (0.6, 3.1, 6.2, and 62.3mg) per day for four consecutive days.

They found that the CBD gel significantly reduced joint swelling. Interestingly, the 62.3mg dose was no more effective than the 6.2mg dose.

Meanwhile, a study published in Frontiers in Immunology in 2018 tested the anti-inflammatory properties of CBD on mice. After applying the cannabinoid for ten days, the researchers found a reduction in inflammatory markers. They used a rodent encephalitis model that imitates the impact multiple sclerosis has on the body.

Scientific data shows that cannabidiol could make pain feel less unpleasant, although it doesn’t reduce experimental pain intensity.

A study conducted at Syracuse University in 2021 again found that CBD has possible pain-relieving effects. It is major news because the team conducted the first-ever experimental pain trial to examine CBD’s effect on humans. The data showed that cannabidiol could make pain feel less unpleasant, although it didn’t reduce experimental pain intensity.

Perhaps most importantly, the researchers found that CBD improved pain measures compared to a placebo. Hopefully, this is the beginning and will lead to the acceptance of CBD as a painkilling option.

Using CBD Oil for Pain

Typically, the advice for using CBD oil involves placing it beneath your tongue and holding it for up to 60 seconds before swallowing. This process ensures that some of the CBD gets into your system sublingually.

However, when it comes to CBD oil for pain, it is perhaps better to apply it directly to the site of the pain. You might find that a topical infused with cannabidiol offers greater absorption than oil. Individuals who rub CBD into the skin for pain often experience a noticeably quicker effect.

If using CBD for the first time, only rub it on a small patch of skin. You need to ensure it doesn’t cause an unwanted reaction. Increase the amount you use gradually until you reach the “minimum therapeutic dose.” This is a term used to denote a situation where you use the smallest amount possible to provide the desired effect.

“CBD is a fascinating compound due to its ability to influence cellular systems throughout the body. Most pharmaceutical medications are linear, meaning they focus on a single channel of the human body. CBD, on the other hand, has a sweeping range of uses thanks to the body’s endocannabinoid system.”

Best CBD Oil for Pain: Side Effects

Although the World Health Organization (WHO) suggests that CBD has a good safety profile, there are potential side effects. These effects are largely minimal compared to the serious side effects of prescription opioids and other painkillers.


The best resource available in terms of highlighting CBD’s side effects comes from the clinical trials of Epidiolex (an FDA-approved cannabidiol drug used in the treatment of rare forms of epilepsy). According to the trials, cannabidiol users may experience:

  • Somnolence
  • Decreased appetite
  • Diarrhea
  • Transaminase elevations
  • Fatigue, malaise, and asthenia
  • Rash
  • Insomnia, sleep disorder, and poor-quality sleep
  • Infections

Furthermore, it is suggested that CBD use may affect liver health, but this is still under investigation. CBD is also known to interact with enzyme processes and drug metabolism. Therefore, it is important to speak with your doctor before considering taking CBD for pain with other drugs.

Now that you know more about CBD oil for pain, let’s check out the best brands and their respective product ranges!

Don’t want to sit and read our best CBD oil for 2022 picks? Watch a quick summary via our video CBD oil countdown instead!

1. PureKana Natural CBD Oil

Top Rated
Based on 215 testers
Pros and Cons of PureKana CBD Oil
Full-spectrum extractPotent, fast-acting results, effectiveThird-party laboratory testedNo pesticides, solvents, or chemical fertilizers
2500mg and 5000mg CBD concentrations only available in natural flavor

PureKana is a unique company that has helped thousands of people across the U.S with its CBD oil drops. It has featured in various major publications, including Forbes and High Times, and is frequently voted as one of the best CBD oil brands.

PureKana uses a unique CO2 extraction process, which provides an almost pure CBD oil. PureKana Natural CBD Oil is an unflavored, dietary and nutritional supplement for increased health and vitality.

It could help manage chronic pain, support recovery from exercise-induced inflammation, reduce swelling, help manage normal daily stresses, and help promote healthy sleep cycles.

Key features of PureKana include:

  • Organic products
  • Non-GMO
  • No pesticides, herbicides, solvents, or chemical fertilizers
  • Non-intoxicating
  • Third-party laboratory tested to ensure safety and potency
  • Free shipping on all products
  • 30-day money-back guarantee

Feel free to view this brand’s large collection of CBD products for the best offers. We also invite you to read our exclusive PureKana CBD review.

PureKana Bottom Line

PureKana was an easy pick for our #1 choice. Our reviewers almost unanimously selected this brand as having the best overall combination of potency, effectiveness, quality, purity, taste, and price-to-value ratio.

Visit Purekana

2. Premium Jane CBD Oil

Top Rated
Based on 215 testers
Pros and Cons of Premium Jane CBD Oil
Full-Spectrum Extract (Made in the USA)Outstanding taste, near-immediate effects according to customersNo artificial flavors or preservatives100% Natural and Organic
No CBD vape oils/vaping productsDoes not offer CBD isolate oil

One of our team members compared Premium Jane’s 1,000 mg full-spectrum oral tincture to other CBD oils on the market. He said it was extremely effective for his chronic back pain, with the effects seeming to last a longer time than other brands’ offerings.

Here are some of the highlights of the Premium Jane lineup:

  • Sourced from CBD-rich hemp grown under the Kentucky Pilot Research Program
  • Delicious natural flavors produced from pure Citrus and Mint oil extracts
  • Full-Spectrum Extract packed with nutrients, terpenes, and more
  • Third-party testing on all products
  • Free shipping and a high standard of customer support

Read our Premium Jane CBD review to learn more about this highly-regarded brand.

Premium Jane Bottom Line

We marveled at the high quality of Premium Jane’s CBD oils, which is why this brand grabbed the #2 spot. Its oils are among the best-tasting around, and customers say it is among the fastest-acting CBD in the industry.

Visit Premium Jane

3. Fab CBD Premium Oil Drops

Top Rated
Based on 215 testers
Pros and Cons of FAB CBD Premium Oil Drops
Appeals to health, exercise, and fitness typesGreat customer relations/customer serviceKnowledgeable and willing to answer questionsAll products are lab tested
No vape products are availableCitrus flavor can be a little overwhelming

FAB CBD has made a serious effort to develop a modern lifestyle brand. If you look at the brand’s website, everything from the web design to the brand labeling to the text it uses screams modern and hip.

Even though FAB CBD is still ranked below our superstar PureKana, it has established itself as a trustworthy brand with a premium product. All of its CBD products are sourced from organically grown Colorado hemp and extracted with pressurized CO2 technology. This is a clear sign that it has spared no expense in manufacturing a top-shelf oil.

In terms of price, its oils are a little cheaper than much of the competition, and it now offers a 2400mg CBD oil. Find out more about what this brand has to offer in our FAB CBD review.

Fab CBD Bottom Line

FAB CBD is a reputable company that emphasizes brand appeal and has garnered quite a large following of fitness and health fanatics. It is a brand worth consideration if you are into health, fitness, and exercise.


4. CBDPure

Top Rated
Based on 215 testers
Pros and Cons of CBDPure
Chemical-free CO2 extraction process90-day money-back guaranteeCertified hemp grown in the U.S.Low priced options
Limited range of products and potenciesNo edibles, vape oils, or vape products

CBDPure hasn’t received the same high-profile accolades as brands like PureKana and Premium Jane. However, it manufactures one of the best CBD oils on the market.

Moreover, it uses third-party lab testing to verify that every batch has perfect cannabinoid profiling. All of its products are free of any harmful microorganisms or pathogens that may have been present in the raw hemp material. The main downsides are the lack of product choice and a maximum CBD oil concentration of 1000mg. Even so, the quality makes up for the lack of choice.

If you would like to learn more about this company, read our CBDPure review today.

CBDPure Bottom Line

While CBDPure isn't ranked in the top 3, it is still one of the most trusted names in the industry. It offers excellent quality products at affordable prices.


5. Hemp Bombs CBD

Top Rated
Based on 215 testers
Pros and Cons of Hemp Bombs CBD
Full-spectrum ExtractDerived from Non-GMO HempMassive 166.6mg CBD per ml of oilFree shipping on orders over $75
CBD oils are rarely discounted300mg is the lowest potency option

Hemp Bombs’ max-strength sublingual tinctures provide a massive 166 mg dose in a single ml. For many people, this is more than enough to help them manage their pain symptoms.

Hemp Bombs is based in Tampa, Florida. In addition to focusing on its products’ purity and therapeutic effectiveness, the brand is dedicated to establishing itself as a top name in the industry with a specific target audience.

Learn more about this brand in our detailed Hemp Bombs CBD review.

Hemp Bombs Bottom Line

Hemp Bombs is mostly known for its huge selection of vape products, but it also offers some of the strongest and most potent CBD oils. Its 5,000mg tincture offers 166.6mg of CBD per ml.


6. Charlotte’s Web

Top Rated
Based on 215 testers
Pros and Cons of Charlotte’s Web
One of the top-selling USA brandsDeveloped by world-famous Stanley Brothers15% off for military veteransOffers specific CBD oil for dogs
More expensive than comparable productsHas received an FDA warning letter in the past

Charlotte’s Web is currently one of the top CBD hemp brands in the United States and is constantly featured on top authority websites such as The Wall Street Journal, Time, and The Huffington Post. What started as a cannabis strain packed with CBD to help a girl named Charlotte Figi soon became an empire.

Today, Charlotte’s Web, formerly known as CW Hemp, offers a wide range of high-quality products derived from hemp, including oils, capsules, and CBD gummies. Its range also includes products with additional cannabinoids such as CBC, CBN, and CBG.

Do you want to know more about this company? If the answer is “yes,” please read our comprehensive Charlotte’s Web CBD oil review.

Charlotte’s Web Bottom Line

Charlotte’s Web is no doubt one of America's best CBD oil companies, although the cost of its product range is a little higher than most of its main rivals.


7. CBDistillery Cannabis Oil

Top Rated
Based on 215 testers
Pros and Cons of CBDistillery Cannabis Oil
Huge selection of CBD dabs/isolatesAlso sells oils containing CBG, CBN, and CBDALow price options for first time CBD users99% pure CBD isolate
Not known for its full-spectrum productsSome customers claim that it takes a long time to get a refund

If you’re looking for maximum potency CBD oil for pain management, then CBDistillery’s range of tinctures is worth checking out. The brand uses a 99% pure CBD isolate that customers have used for everything from stress to insomnia to chronic pain.

Moreover, the folks at CBDistillery are renowned for being some of the most passionate, knowledgeable, and honest in the industry. The brand is completely transparent and has nothing to hide in its products or manufacturing processes. Learn more about this excellent brand in our CBDistillery review.

CBDistillery Bottom Line

CBDistillery has built up a massive following of loyal customers, most of whom prefer the company's line of dabs, shatter, wax and isolates. It is an option for those who enjoy ultra-potent CBD concentrates.


8. Joy Organics CBD

Top Rated
Based on 215 testers
Pros and Cons of Joy Organics CBD
Premium broad-spectrum CBD productsA unique extraction process that creates consistencyLab-tested products to provide a premium product30-day money-back guarantee on all products
Not the cheapest brand aroundCould have an easier purchasing process

With so many brands on the market, it’s often hard to find a reputable, high-quality one. Joy Organics has distinguished itself as one of the best in the industry, so we’ve ranked it number 8 on our best CBD oil list.

What started as a small-run family business has turned into a CBD powerhouse in recent years. Apart from having a huge online presence, Joy Organics also has physical locations in Austin, Texas, Deer Park, Illinois, and Fort Collins, Colorado.

Joy Organics is a brand that believes in variety. It claims that all its products contain zero harsh chemicals and have astonishing absorption rates. Therefore, you’ll find a wide range of products on its site, from CBD oils to CBD bath bombs and even energy drinks.

Unlike many other brands, Joy Organics has created premium-grade broad-spectrum products. The best part about this brand is that it stands behind its products by offering a 30-day money-back guarantee.

Check out our full Joy Organics CBD Review Here.

Joy Organics Bottom Line

Joy Organics CBD is one of the best brands for high-quality, broad-spectrum CBD oils. It also offers free shipping on all orders with no minimum requirements!


9. CBD Essence

Top Rated
Based on 215 testers
Pros and Cons of CBD Essence
Medicinal grade hemp extractDelicious CBD oil candy ediblesFast shipping + great customer serviceAn experienced & reputable brand
Its lower CBD oil concentrations are relatively expensiveYou have to receive approval for refunds

Some people say that CBD Essence’s tincture is the best CBD oil for pain and anxiety. The brand offers an “advanced and natural formula” based on unique extraction processes. Also, a team of pharmacists helps employ state-of-the-art technology in formulating the tincture.

CBD Essence’s range of CBD oils is full-spectrum, so you benefit from multiple cannabinoids and terpenes in what’s known as the “entourage effect.”

The brand has increased the CBD concentration of its available oils, and you can now purchase 2100mg and 2400mg bottles. It also sells hemp edibles, capsules, vape liquids, topicals, and pet care products.

Check out its full range of CBD options on the official site or read our complete CBD Essence Review.

CBD Essence Bottom Line

CBD Essence hemp extract oil is a good option for those looking to save money on their monthly CBD supply. You benefit from a slight discount when you buy four bottles at a time via the CBD Bundles page, although it only offers this option with its 300mg oil.


10. Elixinol CBD Tincture

Top Rated
Based on 215 testers
Pros and Cons of Elixinol CBD Tincture
One of the industry’s most trusted names5% of every purchase goes to charitySustainable seed-to-shelf operationSourced from 100% certified organic hemp
Not many flavors to choose fromNot the cheapest products on the market

Elixinol has a wide range of products, but its CBD Tincture does the trick. It’s the cream of the crop regarding CBD oils, which is reflected in its price. One dropper (1ml) from the 500mg series contains 16.67mg of CBD. This allows you to get precise amounts of CBD, and no guesswork is required. Elixinol has received numerous awards for its products and extraction process.

It is staffed by experts in the hemp industry and offers full-spectrum and broad-spectrum CBD products. Elixinol also sells everyday rapid CBD liposomes, which are supposed to provide you with a higher absorption rate. The brand’s CBD oil collection is relatively expensive, and it lacks the flavors of many of its competitors. Nonetheless, it is an excellent option if you want straightforward cannabidiol that could offer the benefits you seek.

Learn more about this company in our Elixinol CBD review.

Elixinol Bottom Line

Elixinol is one of only a handful of brands that have developed a rock-solid reputation among the entire CBD industry over the last few years. Exclusive coupon code for all Elixinol products: 10off591)

  • Full range of CBD products
  • Nationwide fast and reliable delivery
  • Highly concentrated extraction process
  • Lab results for all products
Shop now
Purekana CBD Oil
  • Full-spectrum extract, 99% pure
  • Potent, fast-acting results
  • Third-party laboratory tested
  • No pesticides, solvents, or chemical fertilizers
Shop now
Premium Jane
  • Full-Spectrum extract (made in USA)
  • Incredible taste, near-immediate effects
  • No artificial flavors or preservatives
  • 100% natural and organic
Shop now
CBD Pure
  • Chemical-free CO2 extraction
  • 90-day money-back guarantee
  • Certified U.S. grown hemp
  • Excellent customer support
Shop now

Choosing the Best CBD for Pain: 6 Things to Consider

One of the major problems plaguing the CBD industry is a lack of regulation. It has long been dubbed the “Wild West” in regulatory terms. The FDA has approved Epidiolex, a pharmaceutical drug containing CBD, for certain conditions. Industrial hemp containing a maximum of 0.3% THC by dry weight is also legal to cultivate with a license.

However, the FDA has NOT approved CBD or any other cannabinoid as a pain medication. While some states, such as Florida, have implemented laws relating to the CBD industry, many locations have practically no rules.

Therefore, any individual or entity can create and sell CBD products with minimal oversight. The result is a slew of unsuitable and potentially dangerous products.

Plenty of published studies have exposed issues with mislabeling and contaminants. One of the latest was published in Missouri Medicine in 2020 and noted that the FDA studied 102 products that claimed a specific CBD content. Eighteen of these products contained less than 80% of the amount claimed on the product label. Another 38 had over 120% of the indicated CBD level, while almost half the products contained measurable levels of THC.

Therefore, customers need to know what they’re getting. We invite you to try one of the CBD brands we’ve reviewed above. However, if you want to perform further research, here are some tips for buying cannabidiol safely.

1 – Hemp Source

Everything begins with where a brand gets its hemp from. In simple terms, avoid any company that doesn’t source its hemp from a licensed farm in the United States or the EU. States such as Kentucky and Colorado have developed a reputation for cultivating the best hemp in the world.

2 – Extraction Method

Steer clear of any company that uses butane extraction, as its products could contain harmful residual solvents. Certain reputable brands utilize food-grade ethanol extraction and claim this method ensures a greater level of terpenes and cannabinoids in a product.

The FDA considers ethanol a Class 3 solvent, which means it is less toxic than Class 1 and 2 solvents. However, it says that 5,000ppm of ethanol is “acceptable without justification.” Yet, some CBD users don’t want to ingest any solvents.

This is where supercritical CO2 extraction comes into play. It is considered the gold standard of extraction methods because it leaves no residual solvents. The result is a cleaner and purer product.

3 – Third-Party Lab Reports

A brand must submit its CBD products for third–party testing and show certificates of analysis (COA) on its official website.

A COA outlines the cannabinoid content, thus ensuring you don’t fall into the trap of buying the type of products uncovered by the FDA in the research above. It gives you confidence that the THC level is low and indicates the level of residual solvents, pesticides, and other toxins.

Please ensure that the COAs are relatively recent and the testing is performed by a reputable laboratory not affiliated with the brand.

4 – Ingredients

Apart from knowing where the hemp comes from, check the product’s label. Does it provide a detailed outline of the ingredients? Does the CBD oil contain far too many “extras?” We recommend sticking with CBD oils that contain little more than hemp extract, a carrier oil like MCT oil, and perhaps some natural flavoring.

5 – Type of CBD

This suggestion boils down to personal preference. Some users like full-spectrum CBD products because they contain a rich combination of cannabinoids, terpenes, and other compounds. The belief is that this combination unleashes a more beneficial outcome called the “entourage effect.” This term relates to the assertion that hemp’s compounds work better together than in isolation.

There is also broad-spectrum CBD, which contains almost everything a full-spectrum product has, minus the THC. Finally, there is CBD isolate, which contains no other cannabinoids barring cannabidiol. Some brands add terpenes to their products after the initial extraction process.

6 – Brand Reputation

Finally, take note of a company’s general reputation. It seems as if a new CBD seller is popping up every day. Ideally, you will make your purchases from a brand with several years in the industry. Check out customer reviews and pay attention to its standard of customer service.

CBD Oil and Pain: Final Thoughts from Daniel J. Isaacman, M.D.

This article provides a wealth of practical information for the individual considering CBD as an adjunctive or alternative treatment for pain and/or anxiety. CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other systemic regulatory systems.

CBD oils have not been reviewed or approved by the FDA to treat these conditions. However, a wealth of literature (both anecdotal and research-related) exists describing CBD’s safety and effectiveness. As discussed in this article, the potential new adopter must be mindful of several important items.

All products are NOT created equal – they differ significantly in strength, absorption, and elimination by the body.

First, only those products sourced from industrial hemp will be considered legal in most states. One must be careful if the product you choose is sourced from the marijuana plant, as those products may contain THC levels above the legal limit in your given state.

Secondly, all products are NOT created equal – they differ significantly in strength, absorption, and elimination by the body and how they are formulated. One should be mindful of the differences in doses available for each product, starting at a low or moderate dose and increasing as needed to find the lowest dose that provides the desired relief.

In this way, one can individualize usage to maximize effectiveness while minimizing risk – a proper goal for using all medicinals.


How Does CBD Work in the Body?

CBD works by activating receptors and neurotransmitters through a network of cannabinoids called the endocannabinoid system (ECS).

Unlike THC, which binds directly to CB1 receptors located in the brain, CBD works in the body by manipulating receptors throughout organ tissues, the immune system, the pain response system, the hormonal system, and other whole-body regulatory systems.

CBD receptors have been found in virtually every cell and tissue type. For this reason, CBD is believed to work on many aspects of human health and behavior – from the subcellular level to the whole-body level and beyond.

CBD is therapeutic because it manipulates body systems at the cellular level and returns afflicted organ systems, tissue systems, and even chemical systems in the central nervous system back to a state of health and homeostasis. This is why it is capable of helping people with conditions such as depression and anxiety and chronic physical ailments such as pain, inflammation, arthritis, and more.

What Else Does CBD Help With?

Aside from two rare forms of epilepsy and tuberous sclerosis complex, the FDA does not recognize the medical use of CBD for any medical condition. That said, numerous reports have shown that the compound may benefit various conditions and ailments. Many have claimed that CBD oil helps them with the challenges of:

  • Alzheimer’s disease
  • Anorexia
  • Anxiety
  • Arthritis
  • Asthma
  • Chronic pain
  • Depression
  • Epilepsy (seizures)
  • Inflammation from various conditions
  • Insomnia
  • Multiple sclerosis
  • Nausea (emesis)
  • Obesity
  • Post-traumatic stress disorder (PTSD)

How Do I Use CBD Oil for Pain?

There is no single right or wrong way to go about it. Many people use higher-strength products for pain than they do for things like anxiety, stress, or depression. The majority of today’s best CBD oil manufacturers offer tinctures in various concentrations of up to 5,000mg.

Some people prefer to consume CBD oil sublingually. This means placing drops beneath the tongue, holding for up to 60 seconds, and swallowing. Yet only some of the CBD gets into the body via the capillaries beneath the tongue. The rest is consumed orally.

However, when it comes to managing pain at a specific site on the body, you might find it better to rub the oil, or a topical infused with CBD, on the affected area. Wait a couple of hours to see how it impacts you. Gradually increase the amount you use until you’re happy with the effects.

Research has shown that topical CBD is potentially effective in reducing arthritis pain. For those without respiratory concerns, vaping can provide the quickest relief. However, CBD oil can last the longest in the system and therefore needs the fewest doses per day. Once you have decided what dose of CBD oil best controls your pain, notice when the effects start to wear off, as that is when you should take more.

Most people who try CBD for pain take it twice daily, covering most of the day. Anecdotal reports state that CBD oil’s effects last for 4 to 6 hours on average. However, this timeframe depends on various factors, including the dose taken and the user’s metabolism.

How Long Does It Take for CBD Oil to Work for Pain?

The time it takes for CBD oil to affect depends on how you take it. Oils take longer to work than inhaled CBD and topicals. CBD oils take about the same time to affect as CBD edibles because most of the oil is metabolized through the same pathways as edibles.

You may find that both start working between 30 and 90 minutes after ingestion. That being said, some users claim to feel a noticeable effect within 15 minutes.

How Much CBD Oil Should I Take for Pain?

CBD oil dosing is very individualized. Many factors affect how much CBD is necessary to address a person’s pain, including their size, metabolism, history of CBD use, and the cause of the pain. For example, pain from autoimmune conditions may take higher doses to address than pain from a sore muscle.

Most specialists recommend “starting low and going slow” when finding a CBD oil dose that works. When titrating, know that sometimes it takes a couple of weeks for some of the cannabinoid levels to build up in the fat cells. Once that happens, it results in a slow but more continuous release of CBD.

The key is to effectively gauge exactly how much CBD oil it takes to start managing your pain. If you start right away with a maximum dose of a 600 mg tincture, you will have no idea how much of the product it took to have an effect. You’ll also not know how much you wasted. This is important because you don’t want to exceed the dosage and develop a tolerance to the active cannabinoids. Then there is the small matter of cost!

If you intend to help reduce chronic pain, begin with a lower amount and proceed from there. If you notice effective results, you can downsize the dose or increase it until positive results are achieved.

Only increase your dosage in small increments so that you can pinpoint exactly how much CBD oil it takes to affect. Also, consult with a physician if you plan on taking CBD with other medication.

How Do You Buy CBD Oil for Pain?

Although most European countries tolerate its use, the laws surrounding CBD worldwide vary. If you’re in the United States, you can generally pick up CBD oil for pain online, as long as the CBD comes from hemp, meaning it has a THC content of less than 0.3%. If you want a CBD oil with more THC, you need to live in a state that allows adult-use cannabis or have an MMJ card in a state with a medical marijuana program.

Are There Other Options if You Can’t Use CBD Oil for Pain?

You may not enjoy the taste or texture of CBD oil, or else you dislike holding it beneath your tongue. You may even find that CBD oil doesn’t help with your pain. There are other options like topical CBD creams if this is the case.

CBD topicals are among the most popular choices for arthritis and other localized pain and inflammation forms. Since the skin acts as a semi-permeable membrane, rubbing CBD-infused creams onto an affected area can potentially reduce pain and inflammation.

Likewise, CBD gummies and other CBD edibles are a great option that some people prefer over CBD oils. One of which is simply because edibles taste a lot better than oil! Lastly, vaping CBD with a vape pen has been another popular use of cannabidiol as a pain relief therapy for some users.

Is There a Huge Difference in Quality Between CBD Oil Brands & Products?

Absolutely. There are many steps in making CBD products, and each one must be completed with the utmost care. This requires spending a significant amount of money, and certain companies cut corners. That’s why some CBD products are no more effective than olive oil – because they contain so little CBD.

Others are potentially contaminated by mold or other toxins. It’s best to use a CBD brand with third-party testing results on its website. This information proves that you’re getting the amount of CBD advertised and are consuming no harmful chemicals.

What’s the Most Important Thing to Look for When Buying CBD Oil for Pain?

Check the quality of the product, and ensure it has the amount of CBD you desire per dose. You can find this data via the third-party lab reports that each CBD company should have available on their website. The reports should show how much CBD (and any other cannabinoids present) are in the oil and whether there are any solvents or toxins.

I Use Prescription Medication. Should I be Concerned About Taking CBD Oil Along with My Medication?

Yes. CBD can interact with certain drugs just like any other medication can. Suppose you think it’s less likely to interact because it’s all-natural. In that case, you should be aware that many medications can’t be taken with grapefruit because even some natural substances can affect the metabolism of medications. This is why it’s always important to see your healthcare provider when starting a new medication, even CBD.

Do I Have to Hold the Oil Under My Tongue for 60+ Seconds? Can’t I Squirt It in My Mouth and Swallow It Instead?

You can, but the bioavailability may be increased and/or sped up if you allow it to sit under the tongue. The oil enters the bloodstream directly once absorbed through the sublingual (under the tongue) tissue. This helps avoid the “first pass” effect, which metabolizes a huge amount of any drug.

However, only a fraction of the CBD gets into your system via the capillaries under your tongue. The rest gets digested and metabolized as you consume it orally, so the improved bioavailability of sublingual CBD consumption is arguably overstated

Does CBD Oil Have Side Effects? Should I Take It with Food?

The most common side effects of CBD are nausea, diarrhea, loss of appetite, dry mouth, and fatigue/dizziness. These are rare but possible and are more likely at higher doses. Taking CBD with food doesn’t minimize the side effects; it can enhance bioavailability and CBD concentration.

What Is CBD Oil Produced From?

CBD oil extract should be extracted from the leaves, stalks, and flowers of hemp. It should not be made from stems or seeds.

Is CBD Oil Legal?

This is still a complex subject. In November 2018, President Trump approved updates to the U.S. Farm Bill. Among other things, these updates legalized hemp production as a commercial crop. It also removed hemp from the DEA’s Schedule I illicit substances list.

As an aside, CBD has technically never been a controlled substance under the Controlled Substances Act (CSA). This is because it isn’t mentioned specifically in the CSA’s text!

Under the new laws, CBD products made from hemp are readily accessible in all 50 states, even if the cannabinoid isn’t explicitly legal.

In the past, many assumed that CBD oil products from top brands were legal simply because they didn’t contain the intoxicating properties of THC. While the THC content of hemp does not exceed 0.3%, this is not the reason for legality.

In recent years, legal cases regarding CBD have been taken to the U.S. Court of Appeals. Hemp Industries Assoc. v. DEA, decided in April 2018, determined that Section 7606 of the U.S. Farm Bill preempts the Controlled Substances Act (CSA). This decision implied that the Farm Bill would win out in the event of a contradiction between the CSA and the Farm Bill.

Of course, now that hemp is no longer listed as a controlled substance, the determination of this case is irrelevant. Overall, the Farm Bill allows for the legal cultivation of industrial hemp, a source of CBD. Yet CBD itself isn’t officially federally legal, even though it was never illegal under the CSA! Yes, we’re aware that this is confusing!

What About CBD from Marijuana?

As we’ve discussed, CBD can also come from the marijuana plant. Therefore, whether or not CBD oil for pain is legal is often a question of which “version” of the cannabis plant it is sourced from. If it is sourced from industrial hemp (which contains less than 0.3% THC), and the hemp is cultivated legally under regulations of the Farm Bill, then it is available in almost every state.

However, it is illegal in some states if sourced from marijuana (i.e., cannabis with a higher THC content). Most of the best CBD oils for pain in dispensaries in states like Colorado, California, and Washington are extracted from marijuana plants — not industrial hemp plants. Unfortunately, these products cannot be sold online and shipped across state lines to “non-legal” states.

Nonetheless, like we just mentioned, CBD oil for pain management sourced from industrial hemp grown under the Farm Bill is, in fact, widely available nationwide. The best CBD oil brands we cover on this site claim to extract their concentrates primarily from American-based industrial hemp supplies, though some use EU-grown hemp.

You have to be careful when selecting CBD oils. Since the cannabis industry is not FDA-regulated, dozens of companies sell low-quality products with unreliable content labeling.

Do You Need a Doctor’s Recommendation to Purchase CBD Oil?

If you buy CBD extracted from hemp, you do not need a doctor’s recommendation to purchase.

Join the discussion

    More comments
    Your subscription has ended
    If you love cannabis and want to support our site, join WayofLeaf Premium today and unlock
    Best of all, part of your membership fee will go towards supporting the fight to legalize cannabis.
    Sign Up for WoL Premium
    Not now Protection Status © 2000 - 2022 All Rights Reserved Digital Millennium Copyright Act Services Ltd. |

    WayofLeaf use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. More Information