Those looking for cannabis products often gravitate towards the most potent options; the items with the highest THC content. Although cannabidiol doesn’t result in an intoxicating high, consumers are now striving to find products with the highest CBD concentrations.
CBD isolate is the “gold standard” if you want an incredibly high percentage of the cannabinoid. This guide will check out the best CBD isolate brands and provide more information on this form of cannabidiol.
- CBD isolates contain a massive concentration of CBD – over 99% in some cases. Compare this to an average CBD oil containing ~30% CBD at most.
- Isolates can pose excellent value for the money, and they are exceptionally versatile with their uses and applications.
- They are easy to dose, and they contain zero THC – which is beneficial for some users worried about drug testing.
- On the flip side, CBD isolates contain no other compounds, meaning you miss out on the entourage effect.
Not in the mood to read the entire review? Check out our Wayofleaf’s Pick for our team’s #1 overall selection:
Brand name | CBDistillery | Medterra | Healthworx |
---|---|---|---|
Label | ![]() | ![]() | ![]() |
Potency | 10/10 | 9.5/10 | 9.5/10 |
Price | 9.5/10 | 8.5/10 | 9/10 |
Duration of Effects | 9/10 | 9.5/10 | 9/10 |
Lab Testing | 10/10 | 9.5/10 | 9/10 |
Online Customer Reviews | 9.5/10 | 9/10 | 7/10 |
Brand Reputation/ Customer Service | 9.5/10 | 9/10 | 7.5/10 |
Overall Score | 9.6/10 | 9.2/10 | 8.5/10 |
Link to Purchase | CHECK PRICE | CHECK PRICE | healthworx.com |
Coupon Code | 15% off: 15OFFCBD | 15% off: MB15 | N/A |
Full Brand Review | Read Full Review | Read Full Review | Read Full Review |
Best CBD Isolate 2023: One Thing We Liked About Each Brand
1. | CBDistillery THC-Free Pure CBD Isolate Oil | The best all-around isolate on the market when you consider the two key factors of price and potency. Medterra seems to be roughly the same quality, but they are more expensive. Check CBDistillery prices. | 9.6 / |
2. | Medterra 99% Pure CBD Extract | See above. Medterra makes an isolate CBD isolate product in their 99% Pure CBD Extract, but they are just a little pricier than CBDistillery which is why they earned second spot. Check Medterra prices. | 9.2 / |
3. | Healthworx 99% CBD Isolate Crystals | The major benefit here is price. While you have to order a larger amount at a time to make the cost benefits worthwhile, there are savings to be had here if you’re a person that goes through a lot of CBD isolate at a time. | 8.5 / |
Top-3 Best CBD Isolate Products | Reviews

CBDistillery provides CBD isolate oils and powders in several different concentrations with their CBDelicious range. Purely on the basis of cost-per-mg, this is the best selection of CBD isolate powders that you can find currently, either online or in stores. CBDistillery is a trustworthy, household name, so you know you’re getting a safe and well-made product that can be used for a variety of purposes.
- One of the most recognized and popular names in the CBD industry
- Made using CBDistillery’s trusted extraction and purification processes
- U.S. Hemp Authority-certified and lab tested to contain 0.0% THC
- Minimum free shipping charge of $75

This was an admittedly tricky review to do because all the products we tested were basically 100% pure cannabidiol. With that in mind, there are subtle differences to consider in terms of price and CBD concentration. CBDistillery products, for example, contain on average 97% or more CBD, which is actually slightly behind both Medterra (99.6% pure) and Healthworx (99%). Because Medterra is a little pricier than both products, however, we feel it deserves the #2 spot on a purely cost basis.
- Infused in an MCT carrier oil and available in three potencies (500mg, 1000mg, 3000mg)
- Sourced from organically-grown, non-GMO hemp
- Sourced, extracted, and pacakged in the USA
- More expensive than its competitors on a cost-per-mg basis

The 99% Isolate Crystals from Healthworx would be a good option if you’re looking for a budget pick. At the time of writing, Healthworx sells their isolate extract for just $19.99 per 1000mg, which is an absolute bargain. However, this is a special offer and is only available select times of the year. Still, its “normal” price of $29.99 is well below its rivals, the only problem is you have to buy bulk quantities in order to purchase from them online.
- Excellent cost benefit if you buy wholesale quantities
- Comes in a crystallized (non-tincture form), which increases the range of uses
- Sourced from 100% pure Colorado-grown hemp
- Only available in bulk orders
WAYOFLEAF’S CHOICE: Why CBDistilelry Makes the Best CBD Isolate
One of the great things about isolate is its relatively low cost. As there is an absence of terpenes and phytocannabinoids, such products ultimately carry a lower price point. Medterra remains the most expensive, though the gap is closing. Its 500mg CBD oil, for example, works out to be less than $80 per 1000mg. However, the potent new 6000mg concentration changes things as it costs well over $100 per 1000mg.
The best CBD isolate powders on the market should cost no more than around $75 for roughly 1,000mg of cannabidiol. CBDistillery comes in around 20% cheaper than this “breaking point” (their prices are always changing which is why we haven’t included their current price here), and this was one of the key reasons our team selected it as the best CBD isolate currently on the market.
That being said, you can easily find CBD isolate online for $40-50 per 1000mg, or even less. Stay away from products like these, however, as there is no telling the methods they used to extract and purify the CBD, or even whether it is a legit CBD isolate product. CBDistillery is a popular, trusted, well-known name, so you can trust that its products are safe and well-made.
What Is CBD Isolate?
Isolate CBD products contain practically nothing other than cannabidiol. It is common to find a crystalline powder or oil that is over 99% pure CBD. It still comes from hemp, but all of the plant matter is removed. This means all other cannabinoids, terpenes, and compounds are stripped away.
For those seeking to use the best CBD tincture with no THC, an isolate product is ideal. Those in favor of the practice believe it offers therapeutic benefits. However, there is a suggestion that because you miss out on the “entourage effect,” a CBD isolate oil is not as effective as its full or broad-spectrum counterparts.
CBD Isolate vs. Other Types of CBD Products
The difference between CBD isolate, broad-spectrum, and full-spectrum, comes down to the variety of compounds used in the product.
Isolate CBD contains up to 99.9% cannabidiol and basically nothing else. There is no THC, CBN, CBC, terpenes, waxes, oils, etc. Certain brands decide to add terpenes to the mix after the initial extraction process separates the CBD. The result is a crystalline powder or solid that is exceptionally versatile.
In contrast, a full-spectrum CBD product contains an array of cannabinoids (including THC), terpenes, flavonoids, and other compounds. Broad-spectrum is similar but contains zero THC. Several studies suggest that a combination of cannabinoids and terpenes provides a synergistic interaction called the ‘entourage effect.’ In essence, this effect boosts the individual impacts of every compound involved.
On the plus side, a CBD isolate tincture is guaranteed to have no THC. That is, as long as you buy from a reputable brand that can provide third-party lab reports. You will also find that it is much easier to measure how much you use. Calculating 99.9% of 1,000mg isn’t too taxing a process!
Additionally, there are numerous ways to consume CBD isolate. As there is no taste, you are not in danger of ‘spoiling’ your food or drink by adding powder.
Despite these differences, manufacturers can use specific high-CBD cannabis plants, like Charlotte’s Web, to produce both full-spectrum and isolate products.
What About the Entourage Effect?
First of all, the jury is still out on whether the entourage effect is real. A study published in the British Journal of Pharmacology in 2011 found that using a combination of cannabinoids and terpenes could help with:
- Inflammation
- Pain
- Seizures
- Anxiety
- Cancer
However, a study published in Cannabis and Cannabinoid Research in 2019 suggested an “absence of entourage.” The researchers found that adding terpenes to THC had no change in CB1 and CB2 receptors. Overall, while full-spectrum may ultimately prove more beneficial, it is still worth using CBD isolate if you:
- Want a versatile CBD product.
- Are looking to use large concentrations of cannabidiol.
- Hope to avoid THC completely.
- Are likely to undergo a company drug screening at some point.
When extracting cannabinoids from hemp or cannabis, manufacturers will inevitably also extract many other compounds. Let’s find out more about how CBD isolate is created.
How Manufacturers Isolate CBD in the Purification Process
It is much easier to create the best pure CBD isolate oil on the market in the modern era. Brands have the option to attempt an ethanol-based extraction. The issue here is ensuring that nothing more than a trace amount of the solvent remains.
Supercritical CO2 extraction is known as the “gold standard.” It involves the use of carbon dioxide as the solvent. There are no concerns over residue, and you get a ‘cleaner’ product. However, the equipment is costly, so CO2 extraction products are usually more expensive.
After the initial extraction process, there are numerous hemp compounds left in the oil.
Producing CBD isolate involves another purification process where the remaining plant material is removed. The process, known as “winterization,” separates the extracts’ waxes, lipids, and fats. It is a process that involves soaking the extract in alcohol. The manufacturer freezes it to separate the pure CBD from the rest of the compounds.
The result is the removal of chlorophyll, terpenes, phytocannabinoids, and other unwanted compounds. Most brands then proceed with various rounds of rotary evaporation to get rid of any further residual materials. They may also embark on preparative chromatography. This is a process that separates cannabinoids by placing them through different chemicals at a variety of speeds. In this case, the company must use distillation to get rid of these added chemicals!
After this complicated process has finished, 99+% pure CBD remains – at least in theory!
Explaining What Exactly a “CBD Isolate Tincture” Is
Some people mistakenly think that the best CBD isolate is available in shatter or wax form only. In reality, a growing number of CBD brands are creating CBD isolate tinctures. The main disadvantage is that most of these products contain far less cannabidiol than the blocks of isolate you can buy.
You can also create a CBD isolate tincture at home with the following ingredients:
- CBD isolate powder
- MCT oil
- A measuring cup or oral syringe
- A sterile glass bottle
- A scoop or a spoon
- A funnel
You need to use the scoop/spoon and funnel to transfer the powder into the container. Measure out the MCT oil and add it to the bottle. Screw the lid on and shake the bottle for up to a minute. At this stage, you require patience as it takes time for the CBD powder to dissolve into the oil. Once it does, it shouldn’t recrystallize out once you store the glass bottle properly.
Now that you have CBD isolate, how do you use it?
How Do I Use CBD Isolate?
At first glance, you probably don’t think a flavorless CBD isolate powder has much use. Yet, it is a remarkably versatile substance. As a powder, you can place it beneath your tongue to consume it sublingually.
As a crystal, it is often added to CBD vape juice to increase the concentration of cannabidiol. Then, it is safe to vape it without clogging your vaping device. Of course, you also have the option to buy CBD isolate oil, and use it as you would full or broad-spectrum tinctures.
All in all, there are plenty of other great isolate CBD consumption ideas – doing a little exploring, crafting some new recipes, and experimenting with dosing is all part of the fun.
We hope that this guide helps you find the best CBD isolate for your needs. In truth, there are several high-quality brands, which made finding the cream of the crop exceedingly tricky. For the most part, you will do well by focusing on brands that can provide third-party lab reports. This document provides clear information on what ingredients each product contains.
It is also advisable to stick with well-established brands in the CBD niche. There are some excellent newcomers, but “old hands” have a long history of satisfying their customers. CBDistillery certainly falls into this category. The Colorado-based brand has dozens of employees and is a significant part of the CBD movement. It has sold its isolate for a long time, and it remains one of the company’s best-selling products.
The main downside is that you don’t get 99.9% CBD. However, a guarantee of 97% at a minimum is enough for most customers, and the high purity option has well over 99%. Find out more by visiting the official CBDistillery website and using our exclusive coupon code: