What Is the Best CBD Isolate? [Explained]

This article may contain links to some of our affiliate partners. These are brands we trust and brands we feel represent the highest quality standards. When clicking links, we may earn commissions to help support our site. Learn more by reading our full disclaimer.
Table of Content

    Those looking for cannabis products often gravitate towards the most potent options; the items with the highest THC content. Although cannabidiol doesn’t result in an intoxicating high, consumers are now striving to find products with the highest CBD concentrations.

    CBD isolate is the “gold standard” if you want an incredibly high percentage of the cannabinoid. This guide will check out the best CBD isolate brands and provide more information on this form of cannabidiol.

    • CBD isolates contain a massive concentration of CBD – over 99% in some cases. Compare this to an average CBD oil containing ~30% CBD at most.
    • Isolates can pose excellent value for the money, and they are exceptionally versatile with their uses and applications.
    • They are easy to dose, and they contain zero THC – which is beneficial for some users worried about drug testing.
    • On the flip side, CBD isolates contain no other compounds, meaning you miss out on the entourage effect.

    Not in the mood to read the entire review? Check out our Wayofleaf’s Pick for our team’s #1 overall selection:

    Brand nameCBDistilleryMedterraHealthworx
    Duration of Effects9/109.5/109/10
    Lab Testing10/109.5/109/10
    Online Customer Reviews9.5/109/107/10
    Brand Reputation/
    Customer Service
    Overall Score9.6/109.2/108.5/10
    Link to PurchaseCHECK PRICECHECK PRICEhealthworx.com
    Coupon Code15% off: 15OFFCBD15% off: MB15N/A
    Full Brand ReviewRead Full ReviewRead Full ReviewRead Full Review

    Best CBD Isolate 2023: One Thing We Liked About Each Brand

    1.CBDistillery THC-Free Pure CBD Isolate OilThe best all-around isolate on the market when you consider the two key factors of price and potency. Medterra seems to be roughly the same quality, but they are more expensive. Check CBDistillery prices.9.6 /
    2.Medterra 99% Pure CBD ExtractSee above. Medterra makes an isolate CBD isolate product in their 99% Pure CBD Extract, but they are just a little pricier than CBDistillery which is why they earned second spot. Check Medterra prices.9.2 /
    3.Healthworx 99% CBD Isolate CrystalsThe major benefit here is price. While you have to order a larger amount at a time to make the cost benefits worthwhile, there are savings to be had here if you’re a person that goes through a lot of CBD isolate at a time.8.5 /

    Top-3 Best CBD Isolate Products | Reviews

    1. CBDistillery THC-Free Pure CBD Isolate Oil
    9.6 / 10

    CBDistillery provides CBD isolate oils and powders in several different concentrations with their CBDelicious range. Purely on the basis of cost-per-mg, this is the best selection of CBD isolate powders that you can find currently, either online or in stores. CBDistillery is a trustworthy, household name, so you know you’re getting a safe and well-made product that can be used for a variety of purposes.

    15% COUPON CODE:
    • One of the most recognized and popular names in the CBD industry
    • Made using CBDistillery’s trusted extraction and purification processes
    • U.S. Hemp Authority-certified and lab tested to contain 0.0% THC
    • Minimum free shipping charge of $75
    Review Comments
    Nice little buzz and sleeping great. Also feeling calmer during the day when I'm not taking them.
    I take two of these softgels every evening. They help tremendously with winding me down for the night and guarantee me a great night of sleep. These are by far my favorite CBDistillery product. If you’re looking for relaxation and stress relief at the end of the day, look no further!
    It’s helps me relax at bedtime and get a restful sleep at night.
    2. Medterra 99% Pure CBD Extract
    9.2 / 10

    This was an admittedly tricky review to do because all the products we tested were basically 100% pure cannabidiol. With that in mind, there are subtle differences to consider in terms of price and CBD concentration. CBDistillery products, for example, contain on average 97% or more CBD, which is actually slightly behind both Medterra (99.6% pure) and Healthworx (99%). Because Medterra is a little pricier than both products, however, we feel it deserves the #2 spot on a purely cost basis.

    15% COUPON CODE:
    • Infused in an MCT carrier oil and available in three potencies (500mg, 1000mg, 3000mg)
    • Sourced from organically-grown, non-GMO hemp
    • Sourced, extracted, and pacakged in the USA
    • More expensive than its competitors on a cost-per-mg basis
    Review Comments
    This CBD oil has Changed my Life for the Better! It works well for my Fibromyalgia and Anxiety as well. The Price is ALL THE WAY RIGHT!!
    I like the CBD oil and have been using it for a couple of years but my gripe is it’s almost impossible to order an extra one. The response from MedTerra is so so.
    My husband, who is older but very physically active, suffers from arthritis and swears by the 1000 tincture. Every night! I also have used it to get through times of extreme stress and I think it was super helpful in just kind of taking the edge off and helping me out.
    3. Healthworx 99% CBD Isolate Crystals
    8.5 / 10

    The 99% Isolate Crystals from Healthworx would be a good option if you’re looking for a budget pick. At the time of writing, Healthworx sells their isolate extract for just $19.99 per 1000mg, which is an absolute bargain. However, this is a special offer and is only available select times of the year. Still, its “normal” price of $29.99 is well below its rivals, the only problem is you have to buy bulk quantities in order to purchase from them online.

    • Excellent cost benefit if you buy wholesale quantities
    • Comes in a crystallized (non-tincture form), which increases the range of uses
    • Sourced from 100% pure Colorado-grown hemp
    • Only available in bulk orders
    Review Comments
    I loved the flavor of this CBD, as well as, the great feeling it gave me too. I will repurchase and try different vapes.
    I love the flavor and the smoothness of it. It helps with my back pain and anxiety. I let my sister try it and she says it helps with her anxiety and mood. Highly recommend it.
    I've been taking lower concentration CBD for over 6 mos & thought it quite good. Changed over to Healthworx 5000 mg a couple of weeks ago & already think it's more effective... ~55% lower dosage cost a real plus, too!

    WAYOFLEAF’S CHOICE: Why CBDistilelry Makes the Best CBD Isolate


    One of the great things about isolate is its relatively low cost. As there is an absence of terpenes and phytocannabinoids, such products ultimately carry a lower price point. Medterra remains the most expensive, though the gap is closing. Its 500mg CBD oil, for example, works out to be less than $80 per 1000mg. However, the potent new 6000mg concentration changes things as it costs well over $100 per 1000mg.

    The best CBD isolate powders on the market should cost no more than around $75 for roughly 1,000mg of cannabidiol. CBDistillery comes in around 20% cheaper than this “breaking point” (their prices are always changing which is why we haven’t included their current price here), and this was one of the key reasons our team selected it as the best CBD isolate currently on the market.

    That being said, you can easily find CBD isolate online for $40-50 per 1000mg, or even less. Stay away from products like these, however, as there is no telling the methods they used to extract and purify the CBD, or even whether it is a legit CBD isolate product. CBDistillery is a popular, trusted, well-known name, so you can trust that its products are safe and well-made.

    What Is CBD Isolate?

    Isolate CBD products contain practically nothing other than cannabidiol. It is common to find a crystalline powder or oil that is over 99% pure CBD. It still comes from hemp, but all of the plant matter is removed. This means all other cannabinoids, terpenes, and compounds are stripped away.

    For those seeking to use the best CBD tincture with no THC, an isolate product is ideal. Those in favor of the practice believe it offers therapeutic benefits. However, there is a suggestion that because you miss out on the “entourage effect,” a CBD isolate oil is not as effective as its full or broad-spectrum counterparts.

    CBD Isolate vs. Other Types of CBD Products

    The difference between CBD isolate, broad-spectrum, and full-spectrum, comes down to the variety of compounds used in the product.

    Isolate CBD contains up to 99.9% cannabidiol and basically nothing else. There is no THC, CBN, CBC, terpenes, waxes, oils, etc. Certain brands decide to add terpenes to the mix after the initial extraction process separates the CBD. The result is a crystalline powder or solid that is exceptionally versatile.

    In contrast, a full-spectrum CBD product contains an array of cannabinoids (including THC), terpenes, flavonoids, and other compounds. Broad-spectrum is similar but contains zero THC. Several studies suggest that a combination of cannabinoids and terpenes provides a synergistic interaction called the ‘entourage effect.’ In essence, this effect boosts the individual impacts of every compound involved.

    On the plus side, a CBD isolate tincture is guaranteed to have no THC. That is, as long as you buy from a reputable brand that can provide third-party lab reports. You will also find that it is much easier to measure how much you use. Calculating 99.9% of 1,000mg isn’t too taxing a process!

    Additionally, there are numerous ways to consume CBD isolate. As there is no taste, you are not in danger of ‘spoiling’ your food or drink by adding powder.

    Despite these differences, manufacturers can use specific high-CBD cannabis plants, like Charlotte’s Web, to produce both full-spectrum and isolate products.

    What About the Entourage Effect?

    First of all, the jury is still out on whether the entourage effect is real. A study published in the British Journal of Pharmacology in 2011 found that using a combination of cannabinoids and terpenes could help with:

    However, a study published in Cannabis and Cannabinoid Research in 2019 suggested an “absence of entourage.” The researchers found that adding terpenes to THC had no change in CB1 and CB2 receptors. Overall, while full-spectrum may ultimately prove more beneficial, it is still worth using CBD isolate if you:

    • Want a versatile CBD product.
    • Are looking to use large concentrations of cannabidiol.
    • Hope to avoid THC completely.
    • Are likely to undergo a company drug screening at some point.

    When extracting cannabinoids from hemp or cannabis, manufacturers will inevitably also extract many other compounds. Let’s find out more about how CBD isolate is created.

    How Manufacturers Isolate CBD in the Purification Process

    It is much easier to create the best pure CBD isolate oil on the market in the modern era. Brands have the option to attempt an ethanol-based extraction. The issue here is ensuring that nothing more than a trace amount of the solvent remains.

    Supercritical CO2 extraction is known as the “gold standard.” It involves the use of carbon dioxide as the solvent. There are no concerns over residue, and you get a ‘cleaner’ product. However, the equipment is costly, so CO2 extraction products are usually more expensive.

    After the initial extraction process, there are numerous hemp compounds left in the oil.

    Producing CBD isolate involves another purification process where the remaining plant material is removed. The process, known as “winterization,” separates the extracts’ waxes, lipids, and fats. It is a process that involves soaking the extract in alcohol. The manufacturer freezes it to separate the pure CBD from the rest of the compounds.

    The result is the removal of chlorophyll, terpenes, phytocannabinoids, and other unwanted compounds. Most brands then proceed with various rounds of rotary evaporation to get rid of any further residual materials. They may also embark on preparative chromatography. This is a process that separates cannabinoids by placing them through different chemicals at a variety of speeds. In this case, the company must use distillation to get rid of these added chemicals!

    After this complicated process has finished, 99+% pure CBD remains – at least in theory!

    Explaining What Exactly a “CBD Isolate Tincture” Is

    Some people mistakenly think that the best CBD isolate is available in shatter or wax form only. In reality, a growing number of CBD brands are creating CBD isolate tinctures. The main disadvantage is that most of these products contain far less cannabidiol than the blocks of isolate you can buy.

    You can also create a CBD isolate tincture at home with the following ingredients:

    • CBD isolate powder
    • MCT oil
    • A measuring cup or oral syringe
    • A sterile glass bottle
    • A scoop or a spoon
    • A funnel

    You need to use the scoop/spoon and funnel to transfer the powder into the container. Measure out the MCT oil and add it to the bottle. Screw the lid on and shake the bottle for up to a minute. At this stage, you require patience as it takes time for the CBD powder to dissolve into the oil. Once it does, it shouldn’t recrystallize out once you store the glass bottle properly.

    Now that you have CBD isolate, how do you use it?

    How Do I Use CBD Isolate?

    At first glance, you probably don’t think a flavorless CBD isolate powder has much use. Yet, it is a remarkably versatile substance. As a powder, you can place it beneath your tongue to consume it sublingually.

    As a crystal, it is often added to CBD vape juice to increase the concentration of cannabidiol. Then, it is safe to vape it without clogging your vaping device. Of course, you also have the option to buy CBD isolate oil, and use it as you would full or broad-spectrum tinctures.

    All in all, there are plenty of other great isolate CBD consumption ideas – doing a little exploring, crafting some new recipes, and experimenting with dosing is all part of the fun.

    Final Summary + Our Team's Top Pick

    We hope that this guide helps you find the best CBD isolate for your needs. In truth, there are several high-quality brands, which made finding the cream of the crop exceedingly tricky. For the most part, you will do well by focusing on brands that can provide third-party lab reports. This document provides clear information on what ingredients each product contains.

    It is also advisable to stick with well-established brands in the CBD niche. There are some excellent newcomers, but “old hands” have a long history of satisfying their customers. CBDistillery certainly falls into this category. The Colorado-based brand has dozens of employees and is a significant part of the CBD movement. It has sold its isolate for a long time, and it remains one of the company’s best-selling products.

    The main downside is that you don’t get 99.9% CBD. However, a guarantee of 97% at a minimum is enough for most customers, and the high purity option has well over 99%. Find out more by visiting the official CBDistillery website and using our exclusive coupon code:

    15% COUPON CODE:
    Join The Discussion

    By clicking "Post Comment” you agree with our Terms of Use and Privacy Policy

    DMCA.com Protection Status © 2000 - 2023 All Rights Reserved Digital Millennium Copyright Act Services Ltd. | DMCA.com

    WayofLeaf use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. More Information