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What Is the Best CBD Isolate? [Explained]

Those looking for cannabis products often gravitate towards the most potent options; the items with the highest THC content. Although cannabidiol doesn’t result in an intoxicating high, consumers are now striving to find products with the highest CBD concentrations.

CBD isolate is the ‘gold standard’ if you want an incredibly high percentage of the cannabinoid. This guide will check out the best CBD isolate brands and provide more information on this form of cannabidiol.

What Is CBD Isolate?

Isolate CBD products contain practically nothing other than cannabidiol. It is common to find a crystalline powder or oil that is over 99% pure CBD. It still comes from hemp, but all of the plant matter is removed. This means all other cannabinoids, terpenes, and compounds are stripped away.

For those seeking to use the best CBD tincture with no THC, an isolate product is ideal. Those in favor of the practice believe it offers therapeutic benefits. However, there is a suggestion that because you miss out on the ‘entourage effect,’ a CBD isolate oil is not as effective as its full or broad-spectrum counterparts.

what is cbd isolate?

Pros and Cons of Using CBD Isolate

  • High CBD concentrations – over 99% in some cases.
  • Excellent value for money.
  • Exceptionally versatile.
  • Contains no THC.
  • Easy to determine how much CBD you consume.
  • With no other compounds, you could miss out on the entourage effect.
  • There are a lot of brands on the market, and not all of them are trustworthy.
  • By itself, isolate has no taste unless you can find a flavored option.
  • The texture of using the powder by itself isn’t particularly pleasant.


Don’t want to read the full review? If so, let us tell you that CBDistillery is the narrow winner. All three brands have their plus points, but CBDistillery has two isolate options and a much lower cost.

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How Does CBD Isolate Differ from Broad and Full-Spectrum Products?

The difference between CBD isolate, broad-spectrum, and full-spectrum, comes down to the variety of compounds used in the product.

Isolate CBD contains up to 99.9% cannabidiol and basically nothing else. There is no THC, CBN, CBC, terpenes, waxes, oils, etc. Certain brands decide to add terpenes to the mix after the initial extraction process separates the CBD. The result is a crystalline powder or solid that is exceptionally versatile.

In contrast, a full-spectrum CBD product contains an array of cannabinoids (including THC), terpenes, flavonoids, and other compounds. Broad-spectrum is similar but contains zero THC. Several studies suggest that a combination of cannabinoids and terpenes provides a synergistic interaction called the ‘entourage effect.’ In essence, this effect boosts the individual impacts of every compound involved.

CBD isolate contains almost pure CBD and no other cannabinoids. It differs from full-spectrum oil, which contains a complete array of cannabis compounds.

On the plus side, a CBD isolate tincture is guaranteed to have no THC. That is, as long as you buy from a reputable brand that can provide third-party lab reports. You will also find that it is much easier to measure how much you use. Calculating 99.9% of 1,000mg isn’t too taxing a process!

Additionally, there are numerous ways to consume CBD isolate. As there is no taste, you are not in danger of ‘spoiling’ your food or drink by adding powder.

Despite these differences, manufacturers can use specific high-CBD cannabis plants, like Charlotte’s Web, to produce both full-spectrum and isolate products.

If the ‘Entourage Effect’ Is More Beneficial, Is There Any Need to Use CBD Isolate?

First of all, the jury is still out on whether the entourage effect is real. A study published in the British Journal of Pharmacology in 2011 found that using a combination of cannabinoids and terpenes could help with:

However, a study published in Cannabis and Cannabinoid Research in 2019 suggested an ‘absence of entourage.’ The researchers found that adding terpenes to THC had no change in CB1 and CB2 receptors. Overall, while full-spectrum may ultimately prove more beneficial, it is still worth using CBD isolate if you:

  • Want a versatile CBD product.
  • Are looking to use large concentrations of cannabidiol.
  • Hope to avoid THC completely.
  • Are likely to undergo a company drug screening at some point.

When extracting cannabinoids from hemp or cannabis, manufacturers will inevitably also extract many other compounds. Let’s find out more about how CBD isolate is created.

CBD Isolate Manufacturers: How Do They Ensure Only CBD Remains During Extraction?

It is much easier to create the best pure CBD isolate oil on the market in the modern era. Brands have the option to attempt an ethanol-based extraction. The issue here is ensuring that nothing more than a trace amount of the solvent remains.

Supercritical CO2 extraction is known as the ‘gold standard.’ It involves the use of carbon dioxide as the solvent. There are no concerns over residue, and you get a ‘cleaner’ product. However, the equipment is costly, so CO2 extraction products are usually more expensive.

After the initial extraction process, there are numerous hemp compounds left in the oil.

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Producing CBD isolate involves another purification process where the remaining plant material is removed. The process, known as ‘winterization,’ separates the extracts’ waxes, lipids, and fats. It is a process that involves soaking the extract in alcohol. The manufacturer freezes it to separate the pure CBD from the rest of the compounds.

The result is the removal of chlorophyll, terpenes, phytocannabinoids, and other unwanted compounds. Most brands then proceed with various rounds of rotary evaporation to get rid of any further residual materials. They may also embark on preparative chromatography. This is a process that separates cannabinoids by placing them through different chemicals at a variety of speeds. In this case, the company must use distillation to get rid of these added chemicals!

After this complicated process has finished, 99+% pure CBD remains – at least in theory!

Is There CBD Isolate Tincture?

Some people mistakenly think that the best CBD isolate is available in shatter or wax form only. In reality, a growing number of CBD brands are creating CBD isolate tinctures. The main disadvantage is that most of these products contain far less cannabidiol than the blocks of isolate you can buy.

You can also create a CBD isolate tincture at home with the following ingredients:

  • CBD isolate powder
  • MCT oil
  • A measuring cup or oral syringe
  • A sterile glass bottle
  • A scoop or a spoon
  • A funnel

You need to use the scoop/spoon and funnel to transfer the powder into the container. Measure out the MCT oil and add it to the bottle. Screw the lid on and shake the bottle for up to a minute. At this stage, you require patience as it takes time for the CBD powder to dissolve into the oil. Once it does, it shouldn’t recrystallize out once you store the glass bottle properly.

Now that you have CBD isolate, how do you use it?

How Do I Use CBD Isolate?

At first glance, you probably don’t think a flavorless CBD isolate powder has much use. Yet, it is a remarkably versatile substance. As a powder, you can place it beneath your tongue to consume it sublingually.

As a crystal, it is often added to CBD vape juice to increase the concentration of cannabidiol. Then, it is safe to vape it without clogging your vaping device. Of course, you also have the option to buy CBD isolate oil, and use it as you would full or broad-spectrum tinctures.

There are plenty of other great isolate CBD consumption ideas. Here are a few of our favorites:

  • Infuse Your Coffee or Tea: It mixes easily with hot drinks if you use high-quality CBD isolate. You won’t even know it’s there! Treat yourself by creating a lavish latte laden with CBD and extra cream!
  • Add to Meals: You can stir the powder into soups, sauces, or stir-fries. Most experts believe cannabidiol’s boiling point is between 320- and 356-degrees Fahrenheit. Keep it below 320 degrees when cooking to stay on the safe side.
  • Spruce up a Smoothie: If you want to blend fruits for a healthy smoothie, add some isolate to the mix. You can also sprinkle some into your juice, stir, and enjoy.
  • CBD Syrup: Create a fast DIY syrup by adding isolate to the honey or syrup you add to your oatmeal or pancakes.
  • Enhanced Topicals: You can add some powder to an existing CBD salve to ensure even more cannabinoids are absorbed into the skin.

What Brand Offers the Best CBD Isolate?

Choosing the best CBD isolate brand was a challenging endeavor. It has become a popular form of consumption, and there are many worthy contenders on the market. However, we finally concluded that the following brands were the top three.

  • Healthworx
  • CBDistillery
  • Medterra

what brand offers the best cbd isolate?

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Best Range of Products

CBDistillery provides CBD isolate oils and powders. Apart from offering tinctures in three concentrations, the brand sells CBDelicious powder from hemp, a broad-spectrum CBD powder, and a full-spectrum option. Only the first option is a true isolate.

The majority of Medterra’s products are isolates. Most brands have a special CBD isolate section to go with their broad-spectrum and full-spectrum items. Medterra does the opposite and sells CBD isolate tinctures, gummies, and topicals.

Healthworx only sells shatter and isolate, but the shatter comes in nine flavors, including Girl Scout Cookies and Strawnana. It is the best selection of CBD isolate powders of the three brands. However, because Healthworx doesn’t sell CBD isolate oils, it loses out to Medterra in overall product variety.


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Best CBD Concentration

This is a tricky category because all products should have almost 100% of the cannabinoid. However, some brands add flavors and other compounds while claiming they are selling isolate! All three companies, in this case, fare extremely well.

CBDistillery products contain a guaranteed 97% or more CBD, which is slightly behind the market leaders. Yet the CBDelicious high purity powder has 99.8% CBD, according to its latest lab report.

All of Healthworx’s products contain at least 99% CBD. This is similar to Medterra, which claims its tincture has 99.6% CBD, among the best in the industry. Nonetheless, we’ve decided to lean towards Healthworx in this category because of their transparency.



Best Extraction Process

CBDistillery provides a lot of information about its process. It uses ethanol extraction to extract the crude oil from plant matter. Next, the oil gets decarboxylated, and then the brand implements the winterization process. At this stage, all that is left is a crystalline powder.

Both Medterra and Healthworx use a CO2 extraction process. For most consumers, this is preferable to ethanol. That said, CBDistillery ensures that there is no residual solvent left behind. The truth is, all three brands excel in terms of extracting their CBD. It is tempting to leave CBDistillery on the sidelines because it uses ethanol, but its products are so clean that it would do the brand a disservice.


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Best CBD Isolate Oil

As we mentioned earlier, it is possible to buy cannabidiol isolate in oil form if you don’t like powder, shatter, or wax. Although many brands now offer a CBD isolate oil option, Healthworx does not sell one. It offers THC-free tinctures in concentrations of 600mg to 5000mg CBD. However, the oil also contains terpenes.

CBDistillery offers 500mg, 1000mg, and 2500mg CBD concentrations in its isolate oil. The latter option contains a whopping 83.33mg of CBD per ml.

However, it is usurped by Medterra, a brand that specializes in CBD isolate oil. Apart from its 500mg, 1000mg, and 3000mg oils, it recently released a 6000mg bottle in 60ml of liquid at a nice price. It is among the highest CBD isolate tincture concentrations you’re likely to find.


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Best Budget Pick

One of the great things about isolate is its relatively low cost. As there is an absence of terpenes and phytocannabinoids, such products ultimately carry a lower price point. Medterra remains the most expensive, though the gap is closing. Its 500mg CBD oil, for example, works out at about $70 per 1000mg. However, the new 6000mg concentration changes things as it costs little more than $33 per 1000mg.

CBDistillery’s most ‘expensive’ CBD isolate powder option costs around $30 for 970+mg of cannabidiol. The CBDelicious option is a couple of bucks cheaper for the same amount of the cannabinoid.

At the time of writing, Healthworx sells its CBD isolate for just $19.99 for 1000mg; a 5000mg container costs just $79.99. This gives it an edge on CBDistillery. However, we’re not sure if this is a special offer. Its ‘normal’ price of $29.99 is slightly above its rival. Its CBD shatter is a lot more expensive at $50 per gram.


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Final Thoughts on the Best CBD Isolate

We hope that this guide helps you find the best CBD isolate for your needs. In truth, there are several high-quality brands, which made finding the cream of the crop exceedingly tricky. For the most part, you will do well by focusing on brands that can provide third-party lab reports. This document provides clear information on what ingredients each product contains.

It is also advisable to stick with well-established brands in the CBD niche. There are some excellent newcomers, but ‘old hands’ have a long history of satisfying their customers. CBDistillery certainly falls into this category. The Colorado-based brand has dozens of employees and is a significant part of the CBD movement. It has sold its isolate for a long time, and it remains one of the company’s best-selling products.

The main downside is that you don’t get 99.9% CBD. However, a guarantee of 97% at a minimum is enough for most customers, and the high purity option has well over 99%. Find out more by visiting the official CBDistillery website.


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Overall Rating – 9.4

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