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Psychedelics and Creativity – Two of a Perfect Pair?

As the effects of psychedelics on mental health are becoming increasingly well-known, so are the effects of psychedelics on increasing creativity.

Psychedelics have influenced creative art and music throughout history. More recently, microdosing psychedelics has become more popularized by tech workers and innovators in Silicon Valley, who have used psychedelics to help their creative problem-solving.

We are beginning to understand better how psychedelics affect the brain and cognition. We will explore how these effects could shape our understanding of why psychedelics and creativity go hand in hand.

The Effect of Psychedelics on Creativity

Scientists have defined creativity as the ability or act of producing novel thoughts. Could the psychological and physical effects of psychedelics help explain why psychedelics increase creativity?

Cognitive Flexibility

Classical psychedelics, including LSD and magic mushrooms, produce an effect by interacting with the serotonin 5-HT2A receptor in the brain. Animal studies have shown the 5-HT2A receptor plays a role in cognitive flexibility.

Cognitive flexibility is the ability to change behavior in response to changes in the environment. An everyday example is driving a different route home because of a road closure or changing a meal plan based on the lack of an ingredient.


Cognitive flexibility is part of creativity, as it involves creating new ideas and ways of thinking to update existing ones. The effects of 5-HT2A receptor activation by psychedelics show how they could increase creativity through improving cognitive flexibility.

Increased cognitive flexibility also highlights why psychedelics are helpful tools in psychological therapy for depression and OCD. These disorders often involve rigid thought patterns, which are hard to change. However, cognitive flexibility allows patients to update their pre-existing thoughts and change their ingrained behaviors.

Increased Divergent Thinking

Divergent thinking is a key component of creativity. Divergent thinking is the ability to form multiple solutions to a single problem, for example, trying to think of many different routes to get from point A to B. The opposite of divergent thinking is convergent thinking, the ability to form a single correct answer to a problem, for example, answering a math equation.

Scientists showed that giving ayahuasca, a brew containing the classic psychedelic DMT, to study participants increased divergent thinking, while simultaneously decreasing convergent thinking.

Another study showed that giving volunteers small doses of psilocybin-containing truffles (“magic truffles”) increased their scores on cognitive tests of divergent thinking. These tests also showed that those who had taken the truffles had more original thoughts than those who didn’t.

Changes in functional connectivity

Functional connectivity is the interaction between two different brain regions. Because psychedelics alter changes in functional connectivity, they may activate connectivity patterns in the brain associated with creativity.

Psychedelics may activate patterns in the brain associated with creativity by altering functional connectivity.

One study showed this might be the case. Volunteers who had taken ayahuasca had their brains imaged. Results showed ayahuasca increased the activation of a group of brain connections called the salience network, a set of brain connections that have been linked with creative thinking.

Furthermore, brain imaging studies show psilocybin increases functional connectivity within brain networks involved in cognition. These brain areas may also play a role in creativity.

Studies on Psychedelics and Creativity

A study carried out in the 1960s investigated the effects of LSD or mescaline on creativity in engineers and architects. The study participants reported that taking LSD helped them form new ideas and develop solutions to problems they had been working on for several months.

In a unique 1950’s experiment, study participants painted a picture of a Kachina doll before and after taking LSD. Professional artists then analyzed the paintings. The Kachina doll paintings after LSD were more abstract and expressionistic compared to before, and the artists judged them as more interesting and aesthetically superior.

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A more recent study conducted by researchers at Maastricht University investigated the effects of psilocybin on creativity. A group of volunteers were given either a dose of psilocybin or a placebo. They took part in creativity tasks before, immediately after, and then seven days after taking the drug. Immediately after taking psilocybin, but not placebo, study participants had more spontaneous creative insights. Following seven days, the psilocybin group also had an increase in their number of new ideas.

As well as full psychedelic doses, microdosing, i.e., taking sub-perceptual small doses of psychedelics over a given time can also increase creativity. One large-scale study collected reports about the common effects people felt from microdosing psychedelics and out of the 278 reports, 104 included increased creative thinking.

How Have Psychedelic Experiences Inspired Artists?

Psychedelics can cause visual and auditory hallucinations. Through perceiving sights and sounds out of the ordinary, visual artists and musicians have used psychedelics to help them create abstract art that often represents their psychedelic experiences.

Visual Art

Psychedelics have likely inspired visual art for thousands of years. Some of the earliest examples of psychedelic inspiration in art are the motifs of mushrooms in Ancient Egyptian hieroglyphics, likely representing psychedelic mushrooms believed to have been used by the Egyptians for religious reasons.

Post-Egyptian era, the Bradshaw Rock Art of Australia, believed to date up to 26,000 years, contains abstract figures with mushrooms that also likely represent psychedelic mushrooms people were using at the time.

The discovery of LSD in 1945 by Albert Hoffman marked the emergence of the 1960s counterculture. Psychedelic poster art was a style of art that emerged with the counterculture and is defined by its kaleidoscopic patterns, abstract and mythical beings, and bright colors. Wes Wilson and Victor Moscoso are some of the most well-known psychedelic poster artists.


During the 1960s, psychedelic use influenced the increasing popularity of op art, short for optical illusion art. The abstract geometric patterns and illusions of shapes moving, vibrating, and disappearing associated with op art are similar to the visual hallucinations associated with LSD and psilocybin.

Alex Gray is a famous psychedelic artist of today, and his intricate paintings attempt to capture the visual hallucinations induced by DMT. Other modern psychedelic artists use computer-generated imagery and animation to create abstract and “trippy” art pieces.

Psychedelic Music

As well as visual art, psychedelics heavily influenced music that emerged in the 1960s counterculture. During the 1960s was the creation of psychedelic rock music.

Similar to the psychedelic experience, where time and sound become distorted, psychedelic rock similarly has irregular time patterns and includes distorted sounds. Music of this genre also often includes prolonged and elaborate instrument solos, which creates a sound representation of being in a free-flowing disconnected state, like that of a psychedelic experience.

Psychedelic rock often includes prolonged and elaborate instrument solos, representative of being in a free-flowing disconnected state.

Some of the most famous psychedelic rock musicians of the 60s include Cream, Jefferson Airplane, Jimmi Hendrix, and the Beatles, who famously produced the iconic album Sgt. Peppers Lonely Heart Club Band following their discovery of LSD.

Besides psychedelic rock, several different electronic music genres are inspired by psychedelics and other psychoactive drugs such as MDMA. These include Acid house, Acid techno, Psychedelic trance, and Goa trance.

Psychedelics and Creativity: The Bottom Line

Since people first began using them, psychedelics have gone hand-in-hand with creativity. Psychedelic art and music blossomed in the 1960s following the discovery of LSD and has evolved into modern culture today. Furthermore, microdosing has become an increasingly popular psychedelics trend, and many users report microdosing has helped improve their creativity.

As researchers learn more about how psychedelics affect the brain, we are beginning to understand how psychedelics might influence creativity. And it will be interesting to see as psychedelics become increasingly popular, how they might shape the future of music, art, and technology.

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