Cannabis and CBD Oil for Epidermolysis Bullosa

Recent research has revealed that cannabis and CBD oil may benefit epidermolysis bullosa, a severe genetic skin disorder. This news could offer a ray of hope to patients with the condition who currently have few satisfactory options for addressing symptoms.

This guide will discuss how cannabis-based compounds help epidermolysis bullosa symptoms and the best way to use them.

What Is Epidermolysis Bullosa?

Epidermolysis bullosa is a severe skin condition that causes fragile skin that blisters with the slightest trauma or friction. It can make life challenging for its sufferers as everyday activities like walking and eating can result in extreme pain.

There are several types of epidermolysis bullosa, which vary from mild to debilitating. The most common classifications include:

  • Epidermolysis bullosa simplex (EBS): The most common form of the disorder tends to have relatively mild symptoms.
  • Dystrophic epidermolysis bullosa (DBS): DBS symptoms can vary from mild to severe.
  • Junctional epidermolysis bullosa (JEB): JEB is a rare and severe form of the disease.
  • Epidermolysis bullosa acquisita (EBA): A similar condition is an autoimmune disorder.

Doctors sub-classify each of these types further depending on whether one area or the whole body is affected.

Epidermolysis Bullosa Symptoms

The symptoms of epidermolysis bullosa can vary depending on the type and severity of the disease. The most common symptoms include:

  • Skin that blisters easily
  • Blisters in the mouth or on the hands and feet
  • High risk of skin infections
  • Scarring, sometimes with white spots called milia
  • Thickened skin and nails
  • Nail deformity or loss
  • Alopecia
  • Dental problems
  • Increased risk of skin cancer
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What Causes Epidermolysis Bullosa?

Epidermolysis bullosa is genetic, meaning that it passes from parent to child.

Experts believe that mutations in any of at least 18 different genes contribute to epidermolysis bullosa.

These mutations can be dominant, meaning that it is possible to inherit epidermolysis bullosa from just one parent. However, they may also be recessive, meaning that both parents must carry genetic mutations to pass on the disease.

The exception to the rule is epidermolysis bullosa acquisita, which is an autoimmune disorder. It occurs when the immune system becomes overactive and attacks healthy tissue. This form of epidermolysis bullosa tends to occur in people over 40, while doctors usually diagnose others during early childhood.

Conventional Epidermolysis Bullosa Treatments (Not Cannabis-Based)

There is no cure for epidermolysis bullosa at present. Treatments aim to manage the symptoms as much as possible by relieving blistering and preventing infections.

Patients may have to learn to puncture their blisters using sterile needles to prevent them from becoming too large. They also need to learn to dress wounds and avoid activities that irritate the skin.

Some lifestyle changes which people with epidermolysis bullosa may find helpful include:

  • Not walking long distances.
  • Avoiding injuries, even minor bumps and scratches.
  • Wearing loose-fitting clothes and natural fabrics.
  • Keeping cool in warm weather.

Doctors can prescribe medication to manage symptoms like pain and skin infections. Nutritional support may also be necessary if a person cannot eat due to blisters in the mouth. In very severe cases, patients may require skin graft surgery.

With so few options available, some epidermolysis bullosa patients have started to treat themselves with cannabis and CBD oil. Let’s look at how these natural therapies might help.

Research on Cannabis and CBD Oil for Epidermolysis Bullosa

There are currently no full-scale clinical trials on cannabis-based medicine for epidermolysis bullosa. However, several case reports have encouraging results.

In 2018, the Pediatric Dermatology journal published an article detailing three patients who used topical CBD for epidermolysis bullosa. All three reported faster skin healing, reduced blistering, and pain relief. One of the participants even managed to stop using opioid painkillers completely.

Three case reports in 2019, this time published in The British Journal of Dermatology, had similar results. However, this time the participants took a combination of CBD and THC. They administered the cannabinoids sublingually (under the tongue). All three patients reported reduced pain and itching, and all decreased their use of analgesic medication.

These initial results are promising, but there is no doubt that further research is necessary. Only large, placebo-controlled trials will confirm the efficacy of cannabis and CBD for epidermolysis bullosa symptoms. Until then, consumers must rely on these case reports.

How Do Cannabis and CBD Oil Help Epidermolysis Bullosa?

Although scientists have yet to determine how cannabinoids could help epidermolysis bullosa, it is possible to make some hypotheses based on current knowledge.

For example, experts know that the endocannabinoid system (ECS) is present in the skin. The ECS is the biological system that cannabinoids like CBD and THC influence.

The ECS operates through a combination of cell receptors and chemicals called endocannabinoids, and its job is to keep the body in a state of balance.

This is especially important in the skin, which is continually regenerating. For instance, if the formation of new skin cells is not carefully regulated, problems such as psoriasis can occur.

A 2019 review in the journal Molecules explains that the ECS could also help to enhance healing. Research on mice has shown that inhibiting the enzyme that breaks down endocannabinoids can lead to faster wound healing. This finding suggests that endocannabinoids have a crucial role in skin repair.

Inhibiting the same enzyme can also stimulate the migration of human keratinocytes from one area to another. These are the cells that produce keratin, the protein that gives our skin strength and flexibility.

Furthermore, the ECS is present in nerve endings in the skin. Therefore, by stimulating this complex system, cannabinoids may reduce some epidermolysis bullosa symptoms, including itching and pain.

How to Use Cannabis and CBD Oil for Epidermolysis Bullosa

Because of limited information, researchers currently do not know the best way to use cannabis and CBD oil for epidermolysis bullosa. However, some things to keep in mind include the following:

One of the most typical ways of using cannabis is smoking. However, this consumption method is not ideal for patients with epidermolysis bullosa. Smoking, especially with tobacco, impairs wound healing. It also hinders the immune system and could make infections more likely.

Therefore, it may be better to use cannabis in an alternative way. Edibles are one option, although they could also present problems if a person has difficulty eating. Therefore, oral sprays, oil-filled capsules, or sublingual oil tinctures might be more suitable.

Fortunately, there are many different ways to consume CBD oil. The most common method is placing a few drops under the tongue and holding them there for a minute before swallowing. Doing this should not pose too many problems for people with epidermolysis bullosa.

Another option is CBD topicals, although users should exercise some caution. Topicals do have a significant advantage when applied directly to the skin. This means that the cannabinoids in these products can access the skin’s ECS without digestion.

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The disadvantage of CBD topicals for epidermolysis bullosa is that one must take great care not to rub the skin too hard. Therefore, anyone choosing topicals should be mindful of how they apply them. It may also be necessary to experiment with a few different brands to find a suitable product.

It is crucial to consult a physician before using either cannabis or CBD for epidermolysis bullosa. They will provide accurate information on dosage and administration based on individual needs.

Final Thoughts on Cannabis and CBD Oil for Epidermolysis Bullosa

Epidermolysis bullosa is a painful condition that is life-limiting and challenging to treat. It seems that marijuana and CBD could offer a glimmer of hope regarding symptoms, although research is in its infancy.

Patients should consult a medical professional before using CBD or cannabis for epidermolysis bullosa or any condition. They should always use cannabis responsibly and within the remit of their state’s specific laws.

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