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5 Best CBD Oils for Fibromyalgia [New Research, and More]

Individuals experiencing the effects of fibromyalgia are searching for alternative methods of treatment to lessen their pain. In recent years, cannabinoids (including non-psychoactive CBD oil) have entered the world as a potential option for chronic pain. Research is continuing to surface on their use for a variety of painful conditions – including fibromyalgia.

Chronic pain is one of the most common reasons people take CBD oil. Fibromyalgia sufferers are beginning to take notice of its potential benefits.

Currently, research is inconclusive as to the effects of cannabis and CBD for fibromyalgia. In fact, there are currently no published studies on the use of CBD oil for fibromyalgia specifically.

However, many of the roughly 6 million Americans who suffer from the painful disease would jump at the opportunity to incorporate a more natural remedy into their lives. Living a pharmaceutical-free life is a goal for many, and various forms of cannabis (including CBD oil) are allowing many to do just that.

What About CBD for Fibromyalgia Specifically?

As for the use of CBD for fibromyalgia, it’s important to remind readers that there is no cure for fibromyalgia. Also, there is no current clinical or academic data linking the use of CBD to fibromyalgia treatment.

There is, however, data that supports the use of CBD for helping with various forms of pain. Fibromyalgia is of course a very painful condition, so is there a possibility that CBD oil could help? Keep reading to discover relevant information about CBD oil, fibromyalgia, chronic pain, and more.

Later in the article we identify five of our favorite CBD oils here at WayofLeaf. This is NOT a list of the ‘best CBD oils for fibromyalgia.’ However, these oils may represent quality options for those interested in implementing CBD into their daily lives.

What You Need to Know About CBD, Fibromyalgia, Pain, and Side Effects

As we discuss above, there are a myriad of studies observing the relationship between CBD and pain. However, CBD appears to work within the body differently to THC, which is another abundant cannabinoid in cannabis. The body contains a complex network of endogenous cannabinoid receptors, which are a class of G-protein coupled receptors. These receptors are found throughout the brain, central nervous system, and peripheral tissues.

When THC interacts with the body, it acts as an agonist on CB1 receptors in the central nervous system. This means that the THC compound binds directly to the receptor in a lock-and-key combination. This is also why marijuana with high THC content produces such mind-altering effects.

CBD appears to work in a more indirect manner. It does not appear to have much of an affinity for binding directly to cannabinoid receptors. Rather, it appears to influence things like receptor-independent pathways and ion channels. In fact, a study from 2019 discusses how treatment with “low-dose CBD” can induce pain-relieving effects in rats via TRPV1 (a non-selective cation channel) activation.

What Does This Mean for Sufferers of Fibromyalgia?

Again, we emphasize the fact that there are currently no published studies specifically discussing the relationship between CBD oil and fibromyalgia. While some media outlets (and even some CBD companies) may make claims that cannabidiol can be used to treat the condition, there is simply no clinical data in place to support such claims.

As such, those inquiring about the use of CBD for fibromyalgia may be interested in learning more about the general pain-relieving potential of CBD. The National Institute of Health’s (NIH) PubChem database identifies the structure and molecular form of CBD, and defines it as a cannabis compound with “analgesic, anti-inflammatory, antineoplastic and chemopreventive activities.”

For sufferers of fibromyalgia, the analgesic (i.e. pain-relieving) and anti-inflammatory activities of CBD are of particular interest. Pain and inflammation are common side effects for many conditions, and although the complete pharmacology of cannabidiol is not yet understood, there is potential that it may be able to help with pain relating to fibromyalgia.

There is an ongoing clinical trial comparing the effects of THC and CBD on chronic non-cancer pain, so hopefully, this study will tell us much more about the specific action of CBD on the body’s pain response. And hopefully, research will soon be conducted that observes the potential effects of CBD for fibromyalgia specifically.

Studies on Cannabinoids (i.e. CBD Oil) for Fibromyalgia

While dedicated studies on CBD oil for fibromyalgia are lacking, there are studies on the use of cannabinoids for fibromyalgia pain. CBD is of course one of many different cannabinoids found in cannabis and hemp, so relationships can, of course, be drawn.

In one study published in 2011, 28 patients with fibromyalgia received various doses of cannabis. (CBD, of course, is a present cannabinoid in many cannabis strains). After receiving a cannabis dose, patients were then tested for pain levels.

After just a couple of hours of cannabis use, many of the test subjects reported a decrease in pain using VAS scoring for analysis. Within the conclusion of the study, scientists observe that “the use of cannabis was associated with beneficial effects on some fibromyalgia symptoms.”

The use of cannabis was associated with beneficial effects on some fibromyalgia symptoms.

PLOS One research study, April 2011

Another study published in 2008 discusses data relating to cannabinoids’ effectiveness for conditions such as migraines and fibromyalgia. In the publication, researchers state that “…migraine, fibromyalgia, IBS, and related conditions display common clinical, biochemical and pathophysiological patterns … that may be suitably treated with cannabinoid medicines.”

Although these two examples only represent a small fraction of cases that portray the therapeutic effects of cannabinoids like CBD, there will hopefully be many, many more studies to come in the future. And clearly, we are hoping for dedicated research on the use of CBD oil for fibromyalgia in the near future.

FAQ | CBD Oil and Fibromyalgia

What is the extraction process for CBD?

Although many methods can be utilized to get potent amounts of CBD out of the plant, companies and vendors with the highest-quality products tend to use a method of extraction that incorporates natural CO2. In a pressurized closed-loop system, carbon dioxide is applied to large amounts of hemp plant material to extract naturally-occurring phytocannabinoids (including CBD). After many rounds of purification, these cannabinoids can be infused into an oil (typically olive or coconut/MCT oil) for easy oral consumption.

How does CBD work and take effect within the body?

The endocannabinoid system within the body becomes activated and stimulated when CBD is consumed, inhaled, or applied to the skin. Once these specialized receptors throughout the nervous system are activated, they begin to work with the body to regulate pathways that have been thrown out of balance. In terms of how CBD might work specifically for fibromyalgia, cannabinoid receptors appear in many peripheral areas of the body. Once activated, these receptors can work to reduce inflammation, lower pain, and improve the immune response.

Does it take a long time for the effects of CBD to be experienced?

Everyone is different, and it is important to remember that CBD products do not produce a psychoactive effect (as do THC products). There’s a chance users may not feel anything in terms of therapeutic relief, but there should be no chance of experiencing anything mind-altering or psychoactive. Many users take CBD oil in the hopes of feeling less pain. Others take it with the aim of achieving an overall sense of calm and relaxation. nd maybe even whole-body relief. Depending on the person, CBD oil can vary in terms of how long it takes to take effect. It may take a while to experiment with different milligram amounts, but this effort is well worth it in the long run.

What do we know about the use of cannabis and CBD for various conditions?

The only FDA-approved medicinal use of CBD is for epilepsy (specifically, for Dravet syndrome and Lennox-Gastaut syndrome). However, there have been studies conducted that observe potential relationships between cannabis or CBD, and a variety of other conditions. Some of these conditions include:

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The Best CBD Oils for Fibromyalgia? Be Wary of Resources That Make Unwarranted Claims

As we discuss at length above, there is no clinical data that specifically identifies the effects of CBD oil for fibromyalgia. Still, there are websites and even some companies out there that make claims and put together lists of the ‘best CBD oils for fibromyalgia.’ Again, there is no reliable data to support such claims or lists.

That being said, there are a handful of CBD oils that over the years we have come to recommend on the grounds of general quality. WayofLeaf has been around since 2016, and these are the CBD oils that consistently rank in terms of quality, reliability, and general effectiveness.

1. PureKana



Many describe PureKana as one of the best cannabis oil producers over the last several years. They feature frequently in several media outlets, and many individuals stand devotedly behind the company’s quality, top-notch products. Not only does PureKana offer variety, but they also include good pricing, fast shipping, and outstanding customer service.

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2. CBD Essence


Some companies believe less is more, while others believe more is more. CBD Essence is the latter option, as they offer an impressive and even mind-blowing variety of products. And of course, all products are carefully extracted, crafted, and formulated with the utmost of professionalism.

CBD Essence is so confident in their quality that they don’t even see a need to specialize in a “core” product. All of their available selections are a potentially essential addition to your CBD collection.

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3. Premium Jane CBD Oil


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PremiumJane offers one of the top CBD formulas on the market and have been featured on numerous top sites. Apart from creating a product that looks good, they also excel in creating a product that is high quality and tested by third-party labs for quality assurance. The company offers an expert level of professionalism, and are one of the only CBD companies in the industry (that we’re aware of) wherein a licensed pharmacist oversees production. Customer service is impeccable, and their products suit a variety of individual needs.

  • Product prices start just $48.00
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  • Highly concentrated CBD extracts

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4. Elixinol

Elixinol appears in a variety of popular news outlets, including The Wall Street Journal. As such, it is safe to say that this company has a remarkable reputation. They provide customers with variety, including CBD extracts that range in potency and pricing. No matter what you are looking for, Elixinol probably has what you need.

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  • Flavored products available for those who dislike raw CBD
  • Strong to mild formulations available
  • Reputable, long-standing company that has received global praise
  • Tinctures start at $39.00

5. CBDpure



CBD Pure specializes in only three core products. These are all pure quality hemp extracts, just with different levels of potency. CBDPure keeps it simple by maintaining complete transparency with their clientele. They also are experts at the formulation and production processes of the select few items they do sell.

If what you desire is a CBD extract and you know exactly what you want out of it, the CBDPure online store makes it easy to place an order and receive your selections fast. They offer quick shipping, as well as an industry-leading 90-day guarantee.

  • 90-day guarantee
  • Organic EU hemp
  • Produced using CO2 extraction methods
  • Tested by third-party labs for purity and quality
  • Infused creams, tinctures, and CBD softgels

Visit the official online store at

Thinking About Trying CBD Oil for Fibromyalgia?

Again, we emphasize the precaution one should take when considering brands or products that describe products or a product as the ‘best CBD oil for fibromyalgia.’ There are certainly many quality CBD oils out there to choose from, but as we discuss at length, there is no clear evidence that any one of them treats fibromyalgia specifically.

If you have any personal or firsthand experience using CBD oil for fibromyalgia, please be sure to leave a comment below. Quality anecdotal information is certainly lacking across the CBD industry, and we are certain that the fibromyalgia community would very much value the insight of someone has personal experience with CBD – whether positive or negative.

Final Takeaway: No Such Thing as the ‘Best CBD Oil for Fibromyalgia’

If you are someone that suffers from the pain and discomfort of fibromyalgia, you’re not alone. Many people are looking for a safe, natural alternative to pharmaceutical medications and treatments, but be wary of the information that’s out there. While some outlets indeed recommend lists of the ‘best CBD oils for fibromyalgia,’ there is no clinical evidence to support such products.

That said, CBD is of course a wonderfully safe and natural compound with few side effects. Just be sure to do your homework when researching a quality product.

We hope you have found this article to be educational and informative. It is important to remember that none of the information written above is medical advice, and thus one should not interpret it as such.

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